H
Hans Senn
Researcher at Hoffmann-La Roche
Publications - 34
Citations - 3425
Hans Senn is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Metabolite. The author has an hindex of 20, co-authored 34 publications receiving 3131 citations.
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Journal ArticleDOI
Probabilistic Quotient Normalization as Robust Method to Account for Dilution of Complex Biological Mixtures. Application in 1H NMR Metabonomics
TL;DR: The probabilistic quotient normalization is introduced in this work, which is based on the calculation of a most probable dilution factor by looking at the distribution of the quotients of the amplitudes of a test spectrum by those of a reference spectrum.
Journal ArticleDOI
Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project.
John C. Lindon,Jeremy K. Nicholson,Elaine Holmes,Henrik Antti,Mary E. Bollard,Hector C. Keun,Olaf Beckonert,Timothy M. D. Ebbels,Michael D. Reily,Donald G. Robertson,Gregory J. Stevens,Peter Luke,Alan P. Breau,Glenn H. Cantor,Roy H. Bible,Urs Niederhauser,Hans Senn,Goetz Schlotterbeck,Ulla G. Sidelmann,Steen Møller Laursen,Adrienne A. Tymiak,Bruce D. Car,Lois D. Lehman-McKeeman,Jean-Marie Colet,Ali Loukaci,Craig E. Thomas +25 more
TL;DR: The role that metabonomics has in the evaluation of xenobiotic toxicity studies is presented here and an evaluation of intersite NMR analytical reproducibility has revealed a high degree of robustness.
Journal ArticleDOI
Summary recommendations for standardization and reporting of metabolic analyses.
John C. Lindon,Jeremy K. Nicholson,Elaine Holmes,Hector C. Keun,Andrew Craig,Jake T M Pearce,Stephen J. Bruce,Nigel Hardy,Susanna-Assunta Sansone,Henrik Antti,Pär Jonsson,Clare A. Daykin,Mahendra Navarange,Richard D. Beger,Elwin Verheij,Alexander Amberg,Dorrit Baunsgaard,Glenn H. Cantor,Lois D. Lehman-McKeeman,Mark Earll,Svante Wold,Erik Johansson,John N. Haselden,Kerstin Kramer,Craig E. Thomas,Johann Lindberg,Ina Schuppe-Koistinen,Ian D. Wilson,Michael D. Reily,Donald G. Robertson,Hans Senn,Arno Krotzky,Sunil Kochhar,Jonathan J. Powell,Frans van der Ouderaa,Robert S. Plumb,Hartmut Schaefer,Manfred Spraul +37 more
TL;DR: The Standard Metabolic Reporting Structures (SMRS) working group outlines its vision for an open, community-driven specification for the standardization and reporting of metabolic studies.
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The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution.
TL;DR: The interpretation of heteronuclear 15N-¿1H¿ NOE data shows the co-existence of flexible regions within an otherwise rigid framework of the protein, which seems to be important in receptor interactions.
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Metabolite profiling of Alzheimer's disease cerebrospinal fluid.
Christian Czech,Peter Berndt,Kristina Busch,Oliver J. Schmitz,Jan C. Wiemer,Veronique Most,Harald Hampel,Jürgen Kastler,Hans Senn +8 more
TL;DR: Significant changes in the metabolite profile of AD patients compared to healthy controls have been identified and increased cortisol levels seemed to be related to the progression of AD and have been detected in more severe forms of AD.