H
Hans W. Mages
Researcher at Robert Koch Institute
Publications - 29
Citations - 5423
Hans W. Mages is an academic researcher from Robert Koch Institute. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 23, co-authored 28 publications receiving 5115 citations. Previous affiliations of Hans W. Mages include University of Erlangen-Nuremberg.
Papers
More filters
Journal ArticleDOI
Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells
Annabell Bachem,Steffen Güttler,Evelyn Hartung,Frédéric Ebstein,Michael Schaefer,Astrid Tannert,Abdulgabar Salama,Kamran Movassaghi,Corinna Opitz,Hans W. Mages,Volker Henn,Peter-Michael Kloetzel,Stephanie Gurka,Richard A. Kroczek +13 more
TL;DR: It is shown that CD141+ DCs are the only cells in human blood that express the chemokine receptor XCR1 and respond to the specific ligand XCL1 by Ca2+ mobilization and potent chemotaxis and defined as professional antigen cross-presenting DCs in the human.
Journal ArticleDOI
Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM
Ulf Korthäuer,Daniel Graf,Hans W. Mages,Francine Brière,M Padayachee,Sue Malcolm,Alberto G. Ugazio,Luigi D. Notarangelo,Roland J. Levinsky,Richard A. Kroczek +9 more
TL;DR: Evidence is presented that point mutations in the TRAP gene give rise to nonfunctional or defective expression of TRAP on the surface of T cells in patients with HIGM1, which is responsible for the observed immunoglobulin isotype defect in HIGm1.
Journal ArticleDOI
Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency
Bodo Grimbacher,Andreas Hutloff,Michael Schlesier,Erik Glocker,Klaus Warnatz,Ruth Dräger,Hermann Eibel,Beate Fischer,Alejandro A. Schäffer,Hans W. Mages,Richard A. Kroczek,Hans H. Peter +11 more
TL;DR: The phenotype of human ICOS deficiency, which differs in key aspects from that of the ICOS−/− mouse, suggests a critical involvement of ICOS in T cell help for late B cell differentiation, class-switching and memory B cell generation.
Journal ArticleDOI
Selective Expression of the Chemokine Receptor XCR1 on Cross-presenting Dendritic Cells Determines Cooperation with CD8+ T Cells
Brigitte G. Dorner,Martin B. Dorner,Xuefei Zhou,Corinna Opitz,Ahmed Mora,Steffen Güttler,Andreas Hutloff,Hans W. Mages,Katja Ranke,Michael Schaefer,Robert Smail Jack,Volker Henn,Richard A. Kroczek +12 more
TL;DR: It is demonstrated that XCR1 is exclusively expressed on murine CD8(+) dendritic cells (DCs) and that XCL1 is a potent and highly specific chemoattractant for this DC subset, and emerges as an integral component in the development of efficient cytotoxic immunity in vivo.
Journal ArticleDOI
Cloning of TRAP, a ligand for CD40 on human T cells
TL;DR: A cDNA clone, designated TRAP (TNF‐related activation protein), isolated from a collection of T cell activation genes, is highly similar to an identified murine CD40 ligand both at the cDNA and the protein levels, and related to tumor necrosis factor/lymphotoxin.