H
Hao Tang
Researcher at Bristol-Myers Squibb
Publications - 53
Citations - 5922
Hao Tang is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Nivolumab & Cancer. The author has an hindex of 22, co-authored 49 publications receiving 4329 citations. Previous affiliations of Hao Tang include University of North Carolina at Chapel Hill & Memorial Sloan Kettering Cancer Center.
Papers
More filters
Journal ArticleDOI
Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial
Anthony B. El-Khoueiry,Bruno Sangro,Thomas Yau,Todd S. Crocenzi,Masatoshi Kudo,Chiun Hsu,Tae You Kim,Su Pin Choo,Jörg Trojan,Theodore H. Welling,Tim Meyer,Yoon-Koo Kang,Winnie Yeo,Akhil Chopra,Jeffrey Anderson,Christine Dela Cruz,Lixin Lang,Jaclyn Neely,Hao Tang,Homa Dastani,Ignacio Melero +20 more
TL;DR: Durable objective responses show the potential of nivolumab for treatment of advanced hepatocellular carcinoma, and safety and tolerability for the escalation phase and objective response rate were primary endpoints.
Journal ArticleDOI
NRF2 regulates serine biosynthesis in non-small cell lung cancer
Gina M. DeNicola,Pei Hsuan Chen,Edouard Mullarky,Jessica Sudderth,Zeping Hu,David Wu,Hao Tang,Yang Xie,John M. Asara,Kenneth E. Huffman,Ignacio I. Wistuba,John D. Minna,Ralph J. DeBerardinis,Lewis C. Cantley +13 more
TL;DR: It is found that NRF2 controls the expression of the key serine/glycine biosynthesis enzyme genes PHGDH, PSAT1 and SHMT2 via ATF4 to support glutathione and nucleotide production and it is shown that expression of these genes confers poor prognosis in human NSCLC.
Journal ArticleDOI
27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth
Qian Wu,Tomonori Ishikawa,Rosa Sirianni,Hao Tang,Jeffrey G. McDonald,Ivan S. Yuhanna,Bonne M. Thompson,Luc Girard,Chieko Mineo,Rolf A. Brekken,Michihisa Umetani,David M. Euhus,Yang Xie,Philip W. Shaul +13 more
TL;DR: It is reported that the cholesterol metabolite 27-hydroxycholesterol (27HC) stimulates MCF-7 cell xenograft growth in mice, and in ER+ breast cancer patients, 27HC content in normal breast tissue is increased compared to that in cancer-free controls, and tumor 27 HC content is further elevated.
Journal ArticleDOI
A community computational challenge to predict the activity of pairs of compounds
Mukesh Bansal,Mukesh Bansal,Jichen Yang,Charles Karan,Michael P. Menden,James C. Costello,James C. Costello,Hao Tang,Guanghua Xiao,Yajuan Li,Jeffrey Allen,Rui Zhong,Beibei Chen,Min Kim,Tao Wang,Laura M. Heiser,Ronald Realubit,Michela Mattioli,Mariano J. Alvarez,Yao Shen,Daniel Gallahan,Dinah S. Singer,Julio Saez-Rodriguez,Yang Xie,Gustavo Stolovitzky,Andrea Califano +25 more
TL;DR: Although the accuracy of predictions was not optimal, it is found that computational prediction of compound-pair activity is possible, and that community challenges can be useful to advance the field of in silico compound-synergy prediction.
Journal ArticleDOI
FGF21 Regulates Sweet and Alcohol Preference
Saswata Talukdar,Bryn M. Owen,Parkyong Song,Genaro Hernandez,Yuan Zhang,Yingjiang Zhou,William T. Scott,Bhavna S. Paratala,Tod Turner,Andrew H. Smith,Barbara Bernardo,Christian P. Müller,Christian P. Müller,Hao Tang,David J. Mangelsdorf,Bryan Goodwin,Steven A. Kliewer +16 more
TL;DR: It is shown that FGF21 administration markedly reduces sweet and alcohol preference in mice and sweet preference in cynomolgus monkeys, raising the possibility that F GF21 administration could affect nutrient preference and other reward behaviors in humans.