H
Hao Wu
Researcher at Emory University
Publications - 94
Citations - 14227
Hao Wu is an academic researcher from Emory University. The author has contributed to research in topics: DNA methylation & Medicine. The author has an hindex of 41, co-authored 79 publications receiving 11801 citations. Previous affiliations of Hao Wu include Johns Hopkins University & University of Kentucky.
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R/qtl: QTL mapping in experimental crosses
TL;DR: R/qtl is an extensible, interactive environment for mapping quantitative trait loci (QTLs) in experimental populations derived from inbred lines and includes functions for estimating genetic maps, identifying genotyping errors, and performing single-QTL and two-dimensional, two- QTL genome scans by multiple methods.
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Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
Xuyu Qian,Ha Nam Nguyen,Mingxi M. Song,Christopher Hadiono,Sarah C. Ogden,Christy Hammack,Bing Yao,Gregory R. Hamersky,Fadi Jacob,Chun Zhong,Ki Jun Yoon,William J. Jeang,Li Lin,Yujing Li,Jai Thakor,Daniel A. Berg,Ce Zhang,Eunchai Kang,Michael Chickering,David W. Nauen,Cheng-Ying Ho,Cheng-Ying Ho,Zhexing Wen,Kimberly M. Christian,Pei Yong Shi,Brady J. Maher,Hao Wu,Peng Jin,Hengli Tang,Hongjun Song,Guo Li Ming +30 more
TL;DR: A miniaturized spinning bioreactor (SpinΩ) is developed to generate forebrain-specific organoids from human iPSCs that recapitulate key features of human cortical development, including progenitor zone organization, neurogenesis, gene expression, and, notably, a distinct human-specific outer radial glia cell layer.
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Increased methylation variation in epigenetic domains across cancer types
Kasper D. Hansen,Winston Timp,Winston Timp,Héctor Corrada Bravo,Héctor Corrada Bravo,Sarven Sabunciyan,Benjamin Langmead,Benjamin Langmead,Oliver G. McDonald,Bo Wen,Hao Wu,Yun Liu,Dinh Diep,Eirikur Briem,Kun Zhang,Rafael A. Irizarry,Rafael A. Irizarry,Andrew P. Feinberg +17 more
TL;DR: Stochastic methylation variation of the same cDMRs, distinguishing cancer from normal tissue, is shown in colon, lung, breast, thyroid and Wilms' tumors, with intermediate variation in adenomas.
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5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging
Keith E. Szulwach,Xuekun Li,Yujing Li,Chun-Xiao Song,Hao Wu,Qing Dai,Hasan A. Irier,Anup K. Upadhyay,Marla Gearing,Allan I. Levey,Aparna Vasanthakumar,Lucy A. Godley,Qiang Chang,Xiaodong Cheng,Chuan He,Peng Jin +15 more
TL;DR: The mapped 5-hmC genome-wide in mouse hippocampus and cerebellum at three different ages allowed us to assess its stability and dynamic regulation during postnatal neurodevelopment through adulthood, and found developmentally programmed acquisition of 5-HMC in neuronal cells.
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Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells
Bo Wen,Hao Wu,Hao Wu,Yoichi Shinkai,Rafael A. Irizarry,Rafael A. Irizarry,Andrew P. Feinberg +6 more
TL;DR: It is found that differentiated tissues show surprisingly large K9-modified regions (up to 4.9 Mb), which are large organized chromatin K9 modifications (LOCKs) and may provide a cell type–heritable mechanism for phenotypic plasticity in development and disease.