H
Harald Paganetti
Researcher at Harvard University
Publications - 392
Citations - 18683
Harald Paganetti is an academic researcher from Harvard University. The author has contributed to research in topics: Proton therapy & Monte Carlo method. The author has an hindex of 67, co-authored 367 publications receiving 15589 citations. Previous affiliations of Harald Paganetti include Paul Scherrer Institute & AT&T.
Papers
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Journal ArticleDOI
Relative biological effectiveness (RBE) values for proton beam therapy.
Harald Paganetti,Andrzej Niemierko,Marek Ancukiewicz,Leo E. Gerweck,Michael Goitein,Jay S. Loeffler,Herman D. Suit +6 more
TL;DR: There is too much uncertainty in the RBE value for any human tissue to propose RBE values specific for tissue, dose/fraction, proton energy, etc, and experimental in vivo and clinical data indicate that continued employment of a generic RBEvalue is reasonable.
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Range uncertainties in proton therapy and the role of Monte Carlo simulations
TL;DR: A significant impact of Monte Carlo dose calculation can be expected in complex geometries where local range uncertainties due to multiple Coulomb scattering will reduce the accuracy of analytical algorithms and in these cases Monte Carlo techniques might reduce the range uncertainty by several mm.
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TOPAS: An innovative proton Monte Carlo platform for research and clinical applications
TL;DR: An innovative proton Monte Carlo platform is developed and a custom-designed TOPAS parameter control system was placed at the heart of the code to meet requirements for ease of use, reliability, and repeatability without sacrificing flexibility.
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Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer
TL;DR: This review can serve as a source for defining input parameters for applying or refining biophysical models and to identify endpoints where additional radiobiological data are needed in order to reduce the uncertainties in proton RBE values to clinically acceptable levels.
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Patient study of in vivo verification of beam delivery and range, using positron emission tomography and computed tomography imaging after proton therapy.
Katia Parodi,Harald Paganetti,Helen A. Shih,S. Michaud,Jay S. Loeffler,Thomas F. DeLaney,Norbert J. Liebsch,John E. Munzenrider,Alan J. Fischman,Antje Knopf,Thomas Bortfeld +10 more
TL;DR: The feasibility of postradiation PET/CT for in vivo treatment verification after proton radiotherapy is demonstrated and some technological and methodological improvements needed for optimal clinical application are indicated.