H
Harish Dharuri
Researcher at Leiden University Medical Center
Publications - 13
Citations - 577
Harish Dharuri is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 11, co-authored 13 publications receiving 499 citations.
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Journal ArticleDOI
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels
Harmen H.M. Draisma,Harmen H.M. Draisma,René Pool,René Pool,Michael Kobl,Rick Jansen,Ann-Kristin Petersen,Anika A. M. Vaarhorst,Idil Yet,Toomas Haller,Ayse Demirkan,Ayse Demirkan,Tõnu Esko,Gu Zhu,Stefan Böhringer,Marian Beekman,Jan B. van Klinken,Werner Römisch-Margl,Cornelia Prehn,Jerzy Adamski,Anton J. M. de Craen,Elisabeth M. van Leeuwen,Najaf Amin,Harish Dharuri,Harm-Jan Westra,Lude Franke,Eco J. C. de Geus,Eco J. C. de Geus,Jouke-Jan Hottenga,Jouke-Jan Hottenga,Gonneke Willemsen,Gonneke Willemsen,Anjali K. Henders,Grant W. Montgomery,Dale R. Nyholt,Dale R. Nyholt,John Whitfield,Brenda W.J.H. Penninx,Tim D. Spector,Andres Metspalu,P. Eline Slagboom,Ko Willems van Dijk,Peter A C 't Hoen,Konstantin Strauch,Nicholas G. Martin,Gert-Jan B. van Ommen,Thomas Illig,Jordana T. Bell,Massimo Mangino,Karsten Suhre,Karsten Suhre,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Christian Gieger,Aaron Isaacs,Cornelia M. van Duijn,Cornelia M. van Duijn,Dorret I. Boomsma,Dorret I. Boomsma +59 more
TL;DR: In a discovery sample of 7,478 individuals of European descent, 4,068 genome- and metabolome-wide significant associations between single-nucleotide polymorphisms (SNPs) and metabolites are found, involving 59 independent SNPs and 85 metabolites.
Journal ArticleDOI
Roux-en-Y Gastric Bypass Surgery, but Not Calorie Restriction, Reduces Plasma Branched-Chain Amino Acids in Obese Women Independent of Weight Loss or the Presence of Type 2 Diabetes
Mirjam A. Lips,Jan B. van Klinken,Vanessa van Harmelen,Harish Dharuri,Peter A C 't Hoen,Jeroen F.J. Laros,Gert-Jan B. van Ommen,Ignace M. C. Janssen,Bert Van Ramshorst,Bart A. van Wagensveld,D. J. Swank,François M. H. van Dielen,Adrie Dane,Amy C. Harms,Rob J. Vreeken,Thomas Hankemeier,Johannes W. A. Smit,Hanno Pijl,Ko Willems van Dijk +18 more
TL;DR: The results indicate that the bypass procedure of RYGB surgery, independent of weight loss or the presence of T2DM, reduces BCAA levels in obese subjects.
Journal ArticleDOI
Insight in Genome-Wide Association of Metabolite Quantitative Traits by Exome Sequence Analyses
Ayse Demirkan,Peter Henneman,Aswin Verhoeven,Harish Dharuri,Najaf Amin,Jan B. van Klinken,Lennart C. Karssen,Boukje de Vries,Axel Meissner,Sibel Göraler,Arn M. J. M. van den Maagdenberg,André M. Deelder,Peter A C 't Hoen,Cornelia M. van Duijn,Ko Willems van Dijk +14 more
TL;DR: Combined GWAS and exome analyses of metabolites detected by high-resolution 1H-NMR is a robust approach to uncover metabolite quantitative trait loci (mQTL), and the likely causative variants in these loci.
Journal ArticleDOI
Downregulation of the acetyl-CoA metabolic network in adipose tissue of obese diabetic individuals and recovery after weight loss
Harish Dharuri,Peter A C 't Hoen,Jan B. van Klinken,Peter Henneman,Jeroen F.J. Laros,Mirjam A. Lips,Fatiha el Bouazzaoui,Gert-Jan B. van Ommen,Ignace M. C. Janssen,Bert Van Ramshorst,Bert A. van Wagensveld,Hanno Pijl,Ko Willems van Dijk,Vanessa van Harmelen +13 more
TL;DR: Four novel genes associated with type 2 diabetes and recovery upon weight loss are reported: ACAT1, ACACA, ALDH6A1 and MTHFD1 represent novel biomarkers in adipose tissue associated withtype 2 diabetes in obese individuals.
Journal ArticleDOI
Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profile
Mattijs M. Heemskerk,Harish Dharuri,Sjoerd A.A. van den Berg,Hulda S. Jónasdóttir,Dick-Paul Kloos,Martin Giera,Ko Willems van Dijk,Vanessa van Harmelen +7 more
TL;DR: Interestingly, the DHA metabolite 19, 20-dihydroxy docosapentaenoic acid (19,20-diHDPA) was increased in plasma of niacin-treated mice, which is indicative for an anti-inflammatory profile and may indirectly contribute to the atheroprotective lipid and lipoprotein profile associated with prolonged niacIn treatment.