Harold H. Sandstead

Bio: Harold H. Sandstead is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Zinc deficiency & Zinc. The author has an hindex of 54, co-authored 152 publications receiving 9871 citations. Previous affiliations of Harold H. Sandstead include Vanderbilt University & United States Department of Agriculture.

Zinc: health effects and research priorities for the 1990s.

Abstract: This review critically summarizes the literature on the spectrum of health effects of zinc status, ranging from symptoms of zinc deficiency to excess exposure. Studies on zinc intake are reviewed in relation to optimum requirements as a function of age and sex. Current knowledge on the biochemical properties of zinc which are critical to the essential role of this metal in biological systems is summarized. Dietary and physiological factors influencing the bioavailability and utilization of zinc are considered with special attention to interactions with iron and copper status. The effects of zinc deficiency and toxicity are reviewed with respect to specific organs, immunological and reproductive function, and genotoxicity and carcinogenicity. Finally, key questions are identified where research is needed, such as the risks to human health of altered environmental distribution of zinc, assessment of zinc status in humans, effects of zinc status in relation to other essential metals on immune function, reproduction, neurological function, and the cardiovascular system, and mechanistic studies to further elucidate the biological effects of zinc at the molecular level.

Biochemical studies on dwarfism, hypogonadism, and anemia.

Abstract: Introduction A syndrome consisting of iron-deficiency anemia, hepatosplenomegaly, dwarfism, and hypogonadism occurring in males in Iran has been described recently by Prasad, Halsted, and Nadimi. 1,2 To account for all the features of the syndrome, it was suggested in the earlier report that these patients were probably zinc deficient. Subsequently, similar patients were studied in Egypt and were found to be zinc deficient. 16 The purpose of this paper is to present results of extensive biochemical studies in such patients, to characterize more fully the nature of this syndrome, and to describe five cases in detail. Clinical Material and Methods Patients were selected from villages near Cairo. The ages, verified by birth certificate in each case, ranged from 12 to 19 years. None of them had any evidence of chronic infections such as tuberculosis, syphilis, or brucellosis. A detailed history and physical examination were carried out on each patient on

Toxic effects of metals

Abstract: Essentiality Toxicity Carcinogenicity Lead(Pb) Exposure Toxicokinetics Toxicity Neurologic, Neurobehavioral, and Developmental Effects in Children Mechanisms of Effects on the Developing Nervous System Peripheral Neuropathy Hematologic Effects Renal Toxicity Lead and Gout Effects on Cardiovascular System Immunotoxicity Bone Effects Reproductive Effects Birth Outcomes Carcinogenicity Other Effects Dose Response Treatment Organic Lead Compounds Mercury (Hg) Exposure Disposition and Toxicokinetics Metabolic Transformation Cellular Metabolism Toxicology Biological Indicators Treatment Nickel (Ni) Exposure Toxicokinetics Essentiality Toxicity Nickel Carbonyl Poisoning Dermatitis Indicators of Nickel Toxicity