Author
Hartwell H. Whisennand
Bio: Hartwell H. Whisennand is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Fulminant hepatic failure & Liver transplantation. The author has an hindex of 13, co-authored 16 publications receiving 880 citations.
Papers
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TL;DR: A device consisting of a highly differentiated human liver cell line cultured in a hollow fiber cartridge is capable of supporting dogs with acetaminopheninduced fulminant hepatic failure for a period long enough for their own livers to resume function, allowing recovery of hepatocytes that would otherwise have lysed.
335 citations
Journal Article•
TL;DR: The results of this study suggest the need for avoidance of technical problems during operations, earlier referral of patients with known abdominal aortic aneurysms, especially the elderly, and early diagnosis with immediate operation for ruptured aneurYSms.
86 citations
TL;DR: An improved model of fulminant hepatic failure in dogs is established, using Buthionine sulfoximine to inactivate glutathione synthesis, and small increments of acetaminophen given intravenously to maintain the plasma level at approximately 200 μg/ml for 20 hr.
73 citations
Journal Article•
TL;DR: Among 76 patients with heart wounds treated over a 4 year period, nine had penetrating injuries to the coronary arteries with clinical presentations of pericardial tamponade, electrocardiographic abnormalities of bundle branch block or ST and T wave changes, and hemothorax.
54 citations
TL;DR: This case describes a patient with cholesteryl ester storage disease who underwent liver transplantation for progressive cirrhosis, portal hypertension, ascites, and uncontrollable gastrointestinal bleeding who is clinically well except for mild hypersplenism and an elevated blood urea nitrogen (BUN) and creatinine.
Abstract: This case describes a patient with cholesteryl ester storage disease who underwent liver transplantation for progressive cirrhosis, portal hypertension, ascites, and uncontrollable gastrointestinal bleeding. Four and one-half years posttransplant, her growth improved, cholesterol levels have returned to normal, and she is clinically well except for mild hypersplenism and an elevated blood urea nitrogen (BUN) and creatinine. Serum triglycerides remain elevated, but there have been no signs of progressive renal, intestinal, vascular, or pulmonary disease.
54 citations
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TL;DR: It is proposed recently that the exchange of migratory leukocytes between the transplant and the recipient with consequent long-term cellular chimerism in both is the basis for acceptance of all whole-organ allografts and xenograftS.
766 citations
TL;DR: In patients with chronic hepatitis B, treatment with fialuridine induced a severe toxic reaction characterized by hepatic failure, lactic acidosis, pancreatitis, neuropathy, and myopathy, probably caused by widespread mitochondrial damage and may occur infrequently with other nucleoside analogues.
Abstract: Background We describe severe and unexpected multisystem toxicity that occurred during a study of the antiviral nucleoside analogue fialuridine (1-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)-5-iodouracil, or FIAU) as therapy for chronic hepatitis B virus infection. Methods Fifteen patients with chronic hepatitis B were randomly assigned to receive fialuridine at a dose of either 0.10 or 0.25 mg per kilogram of body weight per day for 24 weeks and were monitored every 1 to 2 weeks by means of a physical examination, blood tests, and testing for hepatitis B virus markers. Results During the 13th week lactic acidosis and liver failure suddenly developed in one patient. The study was terminated on an emergency basis, and all treatment with fialuridine was discontinued. Seven patients were found to have severe hepatotoxicity, with progressive lactic acidosis, worsening jaundice, and deteriorating hepatic synthetic function despite the discontinuation of fialuridine. Three other patients had mild hepatotoxicity. Se...
562 citations
TL;DR: There are no specific therapies for FHF, however, liver transplantation is recommended for situations in which spontaneous recovery appears unlikely and a suitable liver graft is available for transplantation.
552 citations
TL;DR: Critical issues relevant to the application of cryopreservation methods to tissues are addressed, including heat and mass transfer limitations in these bulk systems, intrinsic differences between isolated and cultured cells, and mechanisms of freezing injury unique to tissue systems.
552 citations
TL;DR: The aim of this study was to estimate the operative mortality of RAAA repair and determine how it has changed over time.
Abstract: Background:
Operative repair of ruptured abdominal aortic aneurysm (RAAA) is associated with a high mortality rate but reported figures vary widely. The aim of this study was to estimate the operative mortality of RAAA repair and determine how it has changed over time.
Methods:
A meta-analysis of all English language literature quoting figures for operative mortality of RAAA repair.
Results:
The pooled estimate for the overall operative mortality rate of RAAA repair from 1955 to 1998 was 48 (95 per cent confidence interval 46 to 50) per cent. Meta-regression analysis of operative mortality over time demonstrated a constant reduction of approximately 3·5 per cent per decade (1954–1997) with an operative mortality rate estimate for the year 2000 of 41 per cent. Seventy-seven studies reported intraoperative mortality but, while this appears to have remained constant over time, there was evidence of the presence of publication bias in the subgroup of papers reporting this outcome. There was no evidence of publication bias for the overall operative mortality outcome.
Conclusion:
Contrary to the conclusion of recent studies, this paper demonstrates a gradual reduction with time in the operative mortality rate of RAAA repair. © 2002 British Journal of Surgery Society Ltd
550 citations