H
Haruhiko Yagi
Researcher at National Institutes of Health
Publications - 244
Citations - 14912
Haruhiko Yagi is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Benzo(a)pyrene & Pyrene. The author has an hindex of 59, co-authored 244 publications receiving 14622 citations. Previous affiliations of Haruhiko Yagi include Kyoto University & University of Maryland, Baltimore County.
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Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease
Shimon Sakaguchi,Masahiro Ono,Ruka Setoguchi,Haruhiko Yagi,Shohei Hori,Zoltan Fehervari,Jun Shimizu,Takeshi Takahashi,Takashi Nomura +8 more
TL;DR: Elucidation of the molecular and cellular basis of this Treg‐mediated active maintenance of self‐tolerance will facilitate both the understanding of the pathogenetic mechanism of autoimmune disease and the development of novel methods of autoimmunity prevention and treatment via enhancing and re‐establishing T Reg‐mediated dominant control over self‐reactive T cells.
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Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer.
Junzo Hamanishi,Masaki Mandai,Masashi Iwasaki,Taku Okazaki,Yoshimasa Tanaka,Ken Yamaguchi,Toshihiro Higuchi,Haruhiko Yagi,Kenji Takakura,Nagahiro Minato,Tasuku Honjo,Shingo Fujii +11 more
TL;DR: Multivariate analysis showed the expression of PD-L1 on tumor cells and intraepithelial CD8+ T lymphocyte count are independent prognostic factors and the PD-1/PD-L pathway can be a good target for restoring antitumor immunity in ovarian cancer.
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Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells
Haruhiko Yagi,Takashi Nomura,Kyoko Nakamura,Sayuri Yamazaki,Toshio Kitawaki,Shohei Hori,Michiyuki Maeda,Masafumi Onodera,Takashi Uchiyama,Shingo Fujii,Shimon Sakaguchi +10 more
TL;DR: FoxP3 is a crucial regulatory gene for the development and function of CD25(+)CD4(+) regulatory T cells, and can be used as their reliable marker for treatment of autoimmune/inflammatory diseases and negative control of various immune responses.
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Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene
M. K. Buening,P. G. Wislocki,Wayne Levin,Haruhiko Yagi,Dhiren R. Thakker,H. Akagi,M. Koreeda,D M Jerina,Allan H. Conney +8 more
TL;DR: Differences in the carcinogenic activities of optically active isomers of a polycyclic hydrocarbon diol epoxide are demonstrated by testing the tumorigenicities and activity of benzo[a]pyrene and the other three optically pure isomers.
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Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.
Alexander W. Wood,Wayne Levin,Anthony Y.H. Lu,Haruhiko Yagi,Oscar Hernandez,D M Jerina,Allan H. Conney +6 more
TL;DR: This work reports the first example of a direct role of epoxide hydrase in the metabolic activation of a chemical to a toxic product in the Salmonella strains TA 1538 and TA 98.