Harutsugu Tatebe

TL;DR: In this paper, the authors developed a novel ultrasensitive immunoassay to quantify plasma tau phosphorylated at threonine 181 (p-tau181) is informative in the diagnosis of AD.

TL;DR: It is demonstrated that α-synuclein inclusions are preferred targets for p62-dependent autophagy, and the autophagic clearance of impaired mitochondria in α- Synuclein inclusion-containing cells was investigated, suggesting that mitochondrial clearance is not prevented by α- synucleinInclusions in HEK293 cells.

TL;DR: This is the first paper that enumerated NDE, ADE, and ODE in human plasma and showed the usefulness of those levels as biomarkers for PD and MSA-P.

TL;DR: Findings suggest that neurosin targets the extracellular alpha-synuclein, a major component of the Lewy bodies commonly observed in dopaminergic neurons of patients with sporadic Parkinson's disease.

TL;DR: These results suggest that Aβ oligomers are more important than SP for NFT formation and the subsequent neurodegeneration, and the domestic cat is a unique animal species that naturally replicates various AD pathologies, especially A β oligomer accumulation, N FT formation, and neuronal loss.