H
Hassan Fahmi
Researcher at Université de Montréal
Publications - 101
Citations - 6154
Hassan Fahmi is an academic researcher from Université de Montréal. The author has contributed to research in topics: Cartilage & Mesenchymal stem cell. The author has an hindex of 36, co-authored 95 publications receiving 5139 citations.
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Journal ArticleDOI
Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
TL;DR: The current knowledge regarding the role of proinflammatory cytokines in the pathophysiology of OA is discussed and the potential of anticytokine therapy in the treatment of this disease is addressed.
Journal ArticleDOI
Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis
Yue Zhang,Faezeh Vasheghani,Ying-Hua Li,Meryem Blati,Kayla Simeone,Hassan Fahmi,Bertrand Lussier,Peter J. Roughley,David Lagares,Jean-Pierre Pelletier,Johanne Martel-Pelletier,Mohit Kapoor +11 more
TL;DR: It is shown for the first time that cartilage-specific ablation of mTOR results in increased autophagy signalling and a significant protection from destabilisation of medial meniscus (DMM)-induced OA associated with a significant reduction in the articular cartilage degradation, apoptosis and synovial fibrosis.
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Cyclooxygenase-2 and prostaglandins in articular tissues.
TL;DR: Overexpression of COX-2 protein in articular tissues is a characteristic feature of arthritic diseases, and elucidating the mechanisms of COx-2 expression and PGE2 production and action will help identify novel and more selective potential drug targets in the treatment of arthyritic diseases.
Journal ArticleDOI
Peroxisome proliferator–activated receptor γ activators inhibit interleukin‐1β–induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes
Hassan Fahmi,John A. Di Battista,Jean-Pierre Pelletier,François Mineau,Pierre Ranger,Johanne Martel-Pelletier +5 more
TL;DR: It is demonstrated that PPARgamma agonists inhibit IL-1beta induction of both NO and MMP-13 in human chondrocytes, probably by interfering with the activation of AP-1 and NF-kappaB.
Journal ArticleDOI
PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage
Faezeh Vasheghani,Yue Zhang,Ying-Hua Li,Meryem Blati,Hassan Fahmi,Bertrand Lussier,Peter J. Roughley,David Lagares,Helal Endisha,Bahareh Saffar,Daniel Lajeunesse,Wayne K Marshall,Y. Raja Rampersaud,Nizar N. Mahomed,Rajiv Gandhi,Jean-Pierre Pelletier,Johanne Martel-Pelletier,Mohit Kapoor +17 more
TL;DR: It is shown that peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor, is essential for the normal growth and development of cartilage and maintains articular cartilage homeostasis, in part, by regulating mTOR pathway.