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Hassan Imran Afridi

Bio: Hassan Imran Afridi is an academic researcher from University of Sindh. The author has contributed to research in topics: Extraction (chemistry) & Detection limit. The author has an hindex of 49, co-authored 299 publications receiving 8867 citations.


Papers
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TL;DR: The results revealed that the major causes of water quality deterioration were related to inflow of effluent from industrial, domestic, agricultural and saline seeps into the lake at site 1 and also resulting from people living in boats and fishing at sites 2 and 3.

587 citations

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TL;DR: The results of this study showed that the mean values of Zn, Mn, and Cr were significantly reduced in blood and scalp-hair samples of diabetic patients as compared to control subjects of both genders, confirming that deficiency and efficiency of some essential trace metals may play a role in the development of diabetes mellitus.
Abstract: There is accumulating evidence that the metabolism of several trace elements is altered in diabetes mellitus and that these nutrients might have specific roles in the pathogenesis and progress of this disease. The aim of present study was to compare the level of essential trace elements, chromium (Cr), copper (Cu), iron (Fe), manganese (Mn), nickel (Ni), and zinc (Zn) in biological samples (whole blood, urine, and scalp hair) of patients who have diabetes mellitus type 2 (n = 257), with those of nondiabetic control subjects (n = 166), age ranged (45–75) of both genders. The element concentrations were measured by means of an atomic absorption spectrophotometer after microwave-induced acid digestion. The validity and accuracy was checked by conventional wet-acid-digestion method and using certified reference materials. The overall recoveries of all elements were found in the range of (97.60–99.49%) of certified values. The results of this study showed that the mean values of Zn, Mn, and Cr were significantly reduced in blood and scalp-hair samples of diabetic patients as compared to control subjects of both genders (p < 0.001). The urinary levels of these elements were found to be higher in the diabetic patients than in the age-matched healthy controls. In contrast, high mean values of Cu and Fe were detected in scalp hair and blood from patients versus the nondiabetic subjects, but the differences found in blood samples was not significant (p < 0.05). These results are consistent with those obtained in other studies, confirming that deficiency and efficiency of some essential trace metals may play a role in the development of diabetes mellitus.

440 citations

Journal ArticleDOI
TL;DR: The bio-concentration factors of all HMs were high in grains of two wheat varieties, TJ-83 and Mehran-89, as compared to other varieties, Anmol and Abadgar grown in the same agricultural plots.

225 citations

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TL;DR: The extraction of elements from sediments with EDTA, to predict the bioavailability of trace and toxic elements, has shown that among them As, Cd and Zn were the most bioavailable elements in lake sediment.

213 citations

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TL;DR: It was observed that the leafy vegetables (spinach, coriander and peppermint) contain higher As levels as compared to ground vegetables and grain crops on dried weight basis, and the estimated daily intake of total As in the diet was 9.2 microg/kg body weight/day.

199 citations


Cited by
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TL;DR: This book by a teacher of statistics (as well as a consultant for "experimenters") is a comprehensive study of the philosophical background for the statistical design of experiment.
Abstract: THE DESIGN AND ANALYSIS OF EXPERIMENTS. By Oscar Kempthorne. New York, John Wiley and Sons, Inc., 1952. 631 pp. $8.50. This book by a teacher of statistics (as well as a consultant for \"experimenters\") is a comprehensive study of the philosophical background for the statistical design of experiment. It is necessary to have some facility with algebraic notation and manipulation to be able to use the volume intelligently. The problems are presented from the theoretical point of view, without such practical examples as would be helpful for those not acquainted with mathematics. The mathematical justification for the techniques is given. As a somewhat advanced treatment of the design and analysis of experiments, this volume will be interesting and helpful for many who approach statistics theoretically as well as practically. With emphasis on the \"why,\" and with description given broadly, the author relates the subject matter to the general theory of statistics and to the general problem of experimental inference. MARGARET J. ROBERTSON

13,333 citations

Journal ArticleDOI
15 Sep 2008-Talanta
TL;DR: A review about the application of response surface methodology (RSM) in the optimization of analytical methods is presented and the theoretical principles and steps for its application are described to introduce readers to this multivariate statistical technique.

4,338 citations

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TL;DR: The present paper describes fundamentals, advantages and limitations of the Box-Behnken design for the optimization of analytical methods, and establishes also a comparison between this design and composite central, three-level full factorial and Doehlert designs.

2,177 citations

16 Jun 2018
TL;DR: In this paper, the authors give an overview of the current understanding of Type 1 diabetes and potential future directions for research and care, and discuss the current state of the art in this area.
Abstract: Summary Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and disease burden. Interventions to preserve β cells have been tested, and several methods to improve clinical disease management have been assessed. However, wide gaps still exist in our understanding of type 1 diabetes and our ability to standardise clinical care and decrease disease-associated complications and burden. This Seminar gives an overview of the current understanding of the disease and potential future directions for research and care.

1,326 citations

Journal ArticleDOI

1,148 citations