H
Hassan Pajouhesh
Researcher at Stanford University
Publications - 53
Citations - 1244
Hassan Pajouhesh is an academic researcher from Stanford University. The author has contributed to research in topics: Calcium channel & Voltage-dependent calcium channel. The author has an hindex of 18, co-authored 52 publications receiving 1087 citations. Previous affiliations of Hassan Pajouhesh include University of British Columbia.
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Journal ArticleDOI
A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity
Lisa M. Johansen,Lisa Evans DeWald,Charles J. Shoemaker,Benjamin G. Hoffstrom,Calli M. Lear-Rooney,Andrea Stossel,Elizabeth A. Nelson,Sue E. Delos,James A. Simmons,Jill M. Grenier,Laura T. Pierce,Hassan Pajouhesh,Joseph Lehar,Lisa E. Hensley,Pamela J. Glass,Judith M. White,Gene G. Olinger +16 more
TL;DR: In this paper, the authors tested ~2600 approved drugs and molecular probes in an in vitro infection assay using the type species, Zaire ebolavirus, and found that most of these antiviral drugs block a late stage of viral entry.
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T-Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing and Suppress Absence Seizures
Elizabeth Tringham,Kim L. Powell,Stuart M. Cain,Kristy Kuplast,Janette Mezeyova,Manjula Weerapura,Cyrus Eduljee,Xinpo Jiang,Paula L. Smith,Jerrie Lynn Morrison,Nigel C. Jones,Emma L. Braine,Gil S. Rind,Molly Fee-Maki,David Parker,Hassan Pajouhesh,Manjeet Parmar,Terence J. O'Brien,Terrance P. Snutch +18 more
TL;DR: The ability of the T-type Ca2+ channel antagonists to inhibit absence seizures and to reduce the duration and cycle frequency of spike-and-wave discharges suggests that these agents have a unique mechanism of action on pathological thalamocortical oscillatory activity distinct from current drugs used in clinical practice.
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Multiple Cationic Amphiphiles Induce a Niemann-Pick C Phenotype and Inhibit Ebola Virus Entry and Infection
Charles J. Shoemaker,Kathryn L. Schornberg,Sue E. Delos,Corinne Scully,Hassan Pajouhesh,Gene G. Olinger,Lisa M. Johansen,Judith M. White +7 more
TL;DR: It is suggested that there are minimally two ways of perturbing NPC1-dependent pathways that can block EBOV entry, increasing the attractiveness of NPC1 as an anti-filoviral therapeutic target.
Journal ArticleDOI
Scaffold-based design and synthesis of potent N-type calcium channel blockers.
Gerald W. Zamponi,Zhong-Ping Feng,Lingyun Zhang,Hossein Pajouhesh,Yanbing Ding,Francesco Belardetti,Hassan Pajouhesh,David Dolphin,Lester A. Mitscher,Terrance P. Snutch +9 more
TL;DR: Upon intraperitoneal administration both compounds exhibit analgesic activity in a rodent model of inflammatory pain and NP118809 further exhibits a number of favorable preclinical characteristics as they relate to overall pharmacokinetics and minimal off-target activity including the hERG potassium channel.
Journal ArticleDOI
A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain
Michael E. Hildebrand,Paula L. Smith,Chris Bladen,Cyrus Eduljee,Jennifer Y. Xie,Lina Chen,Molly Fee-Maki,Clint J. Doering,Janette Mezeyova,Yongbao Zhu,Francesco Belardetti,Hassan Pajouhesh,David Parker,Stephen P. Arneric,Manjeet Parmar,Frank Porreca,Elizabeth Tringham,Gerald W. Zamponi,Terrance P. Snutch +18 more
TL;DR: A novel organic compound stabilizes slow‐inactivated sodium and calcium channels to reduce the excitability of nociceptors and dorsal horn neurons and attenuate neuropathic pain signaling.