H
Hatice Gulcin Ozer
Researcher at Ohio State University
Publications - 69
Citations - 3176
Hatice Gulcin Ozer is an academic researcher from Ohio State University. The author has contributed to research in topics: Chromatin immunoprecipitation & microRNA. The author has an hindex of 16, co-authored 63 publications receiving 2453 citations. Previous affiliations of Hatice Gulcin Ozer include Indiana University.
Papers
More filters
Journal ArticleDOI
Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib
Jennifer A. Woyach,Richard R. Furman,Ta-Ming Liu,Hatice Gulcin Ozer,Marc Zapatka,Amy S. Ruppert,Ling Xue,Daniel Hsieh Hsin Li,Susanne M. Steggerda,Matthias Versele,Sandeep S. Dave,Jenny Zhang,Ayse Selen Yilmaz,Samantha Jaglowski,Kristie A. Blum,Arletta Lozanski,Gerard Lozanski,Danelle F. James,Jacqueline C. Barrientos,Peter Lichter,Stephan Stilgenbauer,Joseph J. Buggy,Betty Y. Chang,Amy J. Johnson,John C. Byrd +24 more
TL;DR: Functional analysis showed that the C481S mutation of BTK results in a protein that is only reversibly inhibited by ibrutinib, which underscores the importance of the B-cell-receptor pathway in the mechanism of action of ibrUTinib in CLL.
Journal ArticleDOI
Ibrutinib Regimens versus Chemoimmunotherapy in Older Patients with Untreated CLL
Jennifer A. Woyach,Amy S. Ruppert,Nyla A. Heerema,Weiqiang Zhao,Allison M Booth,Wei Ding,Nancy L. Bartlett,Danielle M. Brander,Paul M. Barr,Kerry A. Rogers,Sameer A. Parikh,Steven Coutre,Arti Hurria,Jennifer R. Brown,Gerard Lozanski,James S. Blachly,Hatice Gulcin Ozer,Brittny Major-Elechi,Briant Fruth,Sreenivasa Nattam,Richard A. Larson,Harry P. Erba,Mark R. Litzow,Carolyn Owen,Charles S. Kuzma,Jeremy S. Abramson,Richard F. Little,Scott E. Smith,Richard Stone,Sumithra J. Mandrekar,John C. Byrd +30 more
TL;DR: Among older patients with untreated CLL, treatment with ibrutinib was superior to treatment with bendamustine plus rituximab with regard to progression‐free survival, and there was no significant difference among the three treatment groups with respect to overall survival.
Journal ArticleDOI
JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides
Sung Ok Yoon,Dong Ju Park,Jae Cheon Ryu,Hatice Gulcin Ozer,Chhavy Tep,Yong Jae Shin,Tae Hee Lim,Lucia Pastorino,Ajaya J. Kunwar,James C. Walton,Alan H. Nagahara,Kun Ping Lu,Randy J. Nelson,Mark H. Tuszynski,Kun Huang +14 more
TL;DR: AD is revealed as a metabolic disease that is under tight control by JNK3, which induces a translational block by activating AMPK, thereby inhibiting the mTOR pathway and phosphorylates APP at T668, thereby facilitating its endocytosis and subsequent processing.
Journal ArticleDOI
Characterization of CLL exosomes reveals a distinct microRNA signature and enhanced secretion by activation of BCR signaling.
Yuh-Ying Yeh,Hatice Gulcin Ozer,Amy Lehman,Kami J. Maddocks,Lianbo Yu,Amy J. Johnson,John C. Byrd +6 more
TL;DR: This study successfully characterized CLL exosomes, demonstrated the control of BCR signaling in the release of CLLExosome release, and uncovered a disease-relevant exosome microRNA profile.
Journal ArticleDOI
Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer
Hansjuerg Alder,Cristian Taccioli,Cristian Taccioli,Hongping Chen,Yubao Jiang,Karl J. Smalley,Paolo Fadda,Hatice Gulcin Ozer,Kay Huebner,John L. Farber,Carlo M. Croce,Louise Y.Y. Fong +11 more
TL;DR: The finding that ZD causesmiR-31 and miR-21 dysregulation associated with inflammation provides insight into mechanisms whereby ZD promotes ESCC.