H
Hatsumi Nagasawa
Researcher at Colorado State University
Publications - 104
Citations - 5591
Hatsumi Nagasawa is an academic researcher from Colorado State University. The author has contributed to research in topics: Cell killing & DNA repair. The author has an hindex of 40, co-authored 104 publications receiving 5491 citations. Previous affiliations of Hatsumi Nagasawa include Boston Children's Hospital & Harvard University.
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Journal Article
Induction of sister chromatid exchanges by extremely low doses of alpha-particles.
Hatsumi Nagasawa,John B. Little +1 more
TL;DR: Results indicate that genetic damage may be induced by low doses of alpha-radiation in cell nuclei not actually traversed by an alpha-particle in hamster ovary cells irradiated with plutonium-238 source.
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Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: evidence for a bystander effect.
Hatsumi Nagasawa,John B. Little +1 more
TL;DR: In this paper, the authors examined the induction of HPRT mutations in CHO cells exposed to low fluences of (238)Pu alpha particles from a specially constructed irradiator.
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Ku70: A Candidate Tumor Suppressor Gene for Murine T Cell Lymphoma
Gloria C. Li,Honghai Ouyang,Xiaoling Li,Hatsumi Nagasawa,John B. Little,David J. Chen,C. Clifton Ling,Zvi Fuks,Carlos Cordon-Cardo +8 more
TL;DR: It is shown that Ku70 deficiency facilitates neoplastic growth and a novel role of the Ku70 locus in tumor suppression is suggested, which is thought to be related to B but not T lymphocyte maturation.
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Radiation-induced genomic instability: delayed mutagenic and cytogenetic effects of X rays and alpha particles.
TL;DR: The results suggest that among clones showing a high frequency of delayed mutations there may be a subpopulation of cells that are particularly unstable; selection for the slow-growth phenotype has the effect of selecting for this chromosomally unstable subpopulation.
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Heat-induced lethality and chromosomal damage in synchronized Chinese hamster cells treated with 5-bromodeoxyuridine.
TL;DR: Synchronous Chinese hamster cells exposed to heat treatments of 45·5°c were very sensitive during S phase when chromosomal damage could account for cell killing, i.e. as for x-irradiated cells, the 37 per cent survival value for heated cells was observed when there was about one aberration per cell.