Author
Heather M. Hines
Other affiliations: University of Illinois at Urbana–Champaign, University of Iowa, University of Oxford ...read more
Bio: Heather M. Hines is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Heliconius & Heliconius erato. The author has an hindex of 25, co-authored 57 publications receiving 4056 citations. Previous affiliations of Heather M. Hines include University of Illinois at Urbana–Champaign & University of Iowa.
Papers published on a yearly basis
Papers
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University College London1, University of Cambridge2, University of California, Irvine3, University of Maryland, College Park4, University of Oxford5, Smithsonian Institution6, University of Greifswald7, Max Planck Society8, Imperial College London9, Harvard University10, University of East Anglia11, Mississippi State University12, University of Texas at Austin13, Commonwealth Scientific and Industrial Research Organisation14, University of Paris15, University of Hawaii16, California Academy of Sciences17, Williams College18, Yale University19, University of Puerto Rico20, Johns Hopkins University21, North Carolina State University22, University of Bristol23, University of Edinburgh24, Baylor College of Medicine25, Del Rosario University26, University of Exeter27, Boston University28
TL;DR: It is inferred that closely related Heliconius species exchange protective colour-pattern genes promiscuously, implying that hybridization has an important role in adaptive radiation.
Abstract: Sequencing of the genome of the butterfly Heliconius melpomene shows that closely related Heliconius species exchange protective colour-pattern genes promiscuously.
1,103 citations
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University of California, Irvine1, University of Puerto Rico, Río Piedras2, North Carolina State University3, Mississippi State University4, University of Cambridge5, Harvard University6, Human Genome Sequencing Center7, University of Texas MD Anderson Cancer Center8, Duke University9, Smithsonian Tropical Research Institute10
TL;DR: The results show that the cis-regulatory evolution of a single transcription factor can repeatedly drive the convergent evolution of complex color patterns in distantly related species, thus blurring the distinction between convergence and homology.
Abstract: Mimicry—whereby warning signals in different species evolve to look similar—has long served as a paradigm of convergent evolution. Little is known, however, about the genes that underlie the evolution of mimetic phenotypes or to what extent the same or different genes drive such convergence. Here, we characterize one of the major genes responsible for mimetic wing pattern evolution in Heliconius butterflies. Mapping, gene expression, and population genetic work all identify a single gene, optix, that controls extreme red wing pattern variation across multiple species of Heliconius. Our results show that the cis-regulatory evolution of a single transcription factor can repeatedly drive the convergent evolution of complex color patterns in distantly related species, thus blurring the distinction between convergence and homology.
429 citations
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TL;DR: Using DNA sequence data, this work reports the first nearly complete species phylogeny of bumble bees, including most of the 250 known species from the 38 currently recognized subgenera, and provides a firm foundation for reclassification and for evaluating character evolution in the bumble Bees.
Abstract: Bumble bees (Bombus Latreille) occupy a wide diversity of habitats, from alpine meadows to lowland tropical forest, yet they appear to be similar in morphology throughout their range, suggesting that behavioural adaptations play a more important role in colonizing diverse habitats. Notwithstanding their structural homogeneity, bumble bees exhibit striking inter- and intraspecific variation in colour pattern, purportedly the outcome of mimetic evolution. A robust phylogeny of Bombus would provide the framework for elucidating the history of their wide biogeographical distribution and the evolution of behavioural and morphological adaptations, including colour pattern. However, morphological studies of bumble bees have discovered too few phylogenetically informative characters to reconstruct a robust phylogeny. Using DNA sequence data, we report the first nearly complete species phylogeny of bumble bees, including most of the 250 known species from the 38 currently recognized subgenera. Bayesian analysis of nuclear (opsin, EF-1α, arginine kinase, PEPCK) and mitochondrial (16S) sequences results in a highly resolved and strongly supported phylogeny from base to tips, with clear-cut support for monophyly of most of the conventional morphology-based subgenera. Most subgenera fall into two distinct clades (short-faced and long-faced) associated broadly with differences in head morphology. Within the short-faced clade is a diverse New World clade, which includes nearly one-quarter of the currently recognized subgenera, many of which are restricted to higher elevations of Central and South America. The comprehensive phylogeny provides a firm foundation for reclassification and for evaluating character evolution in the bumble bees. © 2007 The Linnean Society of London, Biological Journal of the Linnean Society, 2007, 91, 161–188.
302 citations
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Pennsylvania State University1, Lawrence Berkeley National Laboratory2, Carnegie Institution for Science3, Arizona State University4, University of Cambridge5, National Evolutionary Synthesis Center6, California Academy of Sciences7, University of Florida8, Oregon State University9, Simon Fraser University10, Eötvös Loránd University11, University of Arizona12, University of South Dakota13, University of Delhi14, Howard University15, University of Illinois at Chicago16, Stanford University17, University of Hamburg18, Aberystwyth University19, Oregon Health & Science University20, University of Idaho21, University of Michigan22, University of Chicago23, Cincinnati Children's Hospital Medical Center24, Charité25, Iowa State University26, Babraham Institute27, Academy of Natural Sciences of Drexel University28, Florida State University29, University of Rostock30, University at Buffalo31, Smithsonian Institution32, American Museum of Natural History33, University of Kentucky34, Northern Arizona University35, University of California, Berkeley36, National Institutes of Health37, University of Alabama at Birmingham38, Lund University39, University of Calgary40, University of Bonn41, Duke University42, University of Oregon43, Texas A&M University44, University of Illinois at Urbana–Champaign45
TL;DR: Imagine if the authors could compute across phenotype data as easily as genomic data; this article calls for efforts to realize this vision and discusses the potential benefits.
Abstract: Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility.
292 citations
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TL;DR: This work reconstructs the historical distribution of bumble bees in a temporal framework, estimating divergence times using fossil data and molecular rates derived from the literature, and reveals movements of Bombus concordant with geographic and climatic events of the late Cenozoic.
Abstract: Bumble bees (Bombus )a r ea cold-adapted, largely alpine group that can elucidate patterns of Holarctic historical biogeography, particularly in comparison to the alpine plants with which they likely coevolved. A recently published molecular phylogeny of bumble bees provides uniquely comprehensive species sampling for exploring historical patterns of distribution and diversification. Using this phylogeny and detailed data on extant distributions, I reconstruct the historical distribution of bumble bees in a temporal framework, estimating divergence times using fossil data and molecular rates derived from the literature. The nearly comprehensive phylogeny allows assessment of the tempo of diversification within the bumble bees using lineage-through-time plots and diversification statistics, which have been performed with special consideration to confidence intervals. These analyses reveal movements of Bombus concordant with geographic and climatic events of the late Cenozoic. The initial diversification of extant bumble bee lineages was estimated at around 25 to 40 Ma, near the Eocene-Oligocene boundary 34 Ma, a period of dramatic global cooling. Dispersal-vicariance analysis (DIVA) predicted an Old World Bombus ancestor, with early diversification events largely restricted to the eastern Old World. The numerous intercontinental dispersal events occurred mostly in the direction of Old World to New World and North America to South America. Early movements from the Palearctic into the Nearctic most likely took place after 20 Ma and may have coincided with a period of Miocene cooling that gave rise to taiga habitat across Beringia. Subsequent dispersal between these regions is estimated to have occurred among boreal and tundra-adapted species mostly in the last 5 million years. Radiations are estimated in both Nearctic and Neotropical regions at ∼ 6t o8M aand after 3.5 Ma, concordant with the opening of land corridors between the continents. (Alpine; bumblebees; Holarctic; lineage-through-time; molecular dating.) Bumble bees (Bombus Latr.) are an excellent system for exploring historical biogeographic patterns of cold- adapted, alpine, or Holarctic groups. A long history of taxonomic research on Bombus has resulted in rel- atively well-defined species, with descriptions of cur- rently accepted species plateauing over 50 years ago (Williams, 1998). The distributions of the species are also relatively well documented and encompass a wide geo- graphic range across the cool temperate and cold regions of the Holarctic and beyond, including Eurasia, North America, Africa north of the Sahara, and much of South America (Williams, 1998). Although distributional pat- terns of extant bumble bees suggest possible scenarios for historical biogeography and fossil evidence provides approximate dates for these events, estimation of the ancestral biogeographic distributions of Bombus clades and the temporal framework of such divergences are best examined using a robust phylogeny. Much effort
248 citations
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TL;DR: It is suggested that the natural selection against large insertion/deletion is so weak that a large amount of variation is maintained in a population.
11,521 citations
01 Aug 2000
TL;DR: Assessment of medical technology in the context of commercialization with Bioentrepreneur course, which addresses many issues unique to biomedical products.
Abstract: BIOE 402. Medical Technology Assessment. 2 or 3 hours. Bioentrepreneur course. Assessment of medical technology in the context of commercialization. Objectives, competition, market share, funding, pricing, manufacturing, growth, and intellectual property; many issues unique to biomedical products. Course Information: 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.
4,833 citations
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TL;DR: It is found that fruit, vegetable or seed production from 87 of the leading global food crops is dependent upon animal pollination, while 28 crops do not rely upon animalPollination, however, global production volumes give a contrasting perspective.
Abstract: The extent of our reliance on animal pollination for world crop production for human food has not previously been evaluated and the previous estimates for countries or continents have seldom used primary data. In this review, we expand the previous estimates using novel primary data from 200 countries and found that fruit, vegetable or seed production from 87 of the leading global food crops is dependent upon animal pollination, while 28 crops do not rely upon animal pollination. However, global production volumes give a contrasting perspective, since 60% of global production comes from crops that do not depend on animal pollination, 35% from crops that depend on pollinators, and 5% are unevaluated. Using all crops traded on the world market and setting aside crops that are solely passively self-pollinated, wind-pollinated or parthenocarpic, we then evaluated the level of dependence on animal-mediated pollination for crops that are directly consumed by humans. We found that pollinators are essential for 13 crops, production is highly pollinator dependent for 30, moderately for 27, slightly for 21, unimportant for 7, and is of unknown significance for the remaining 9. We further evaluated whether local and landscape-wide management for natural pollination services could help to sustain crop diversity and production. Case studies for nine crops on four continents revealed that agricultural intensification jeopardizes wild bee communities and their stabilizing effect on pollination services at the landscape scale.
4,830 citations
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TL;DR: Both BlastKOALA and GhostKOalA are automatic annotation servers for genome and metagenome sequences, which perform KO (KEGG Orthology) assignments to characterize individual gene functions and reconstruct KEGG pathways, BRITE hierarchies and K EGG modules to infer high-level functions of the organism or the ecosystem.
2,247 citations