H
Heather Valentine
Researcher at Johns Hopkins University
Publications - 35
Citations - 1539
Heather Valentine is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Electroencephalography & Radioligand. The author has an hindex of 18, co-authored 35 publications receiving 1410 citations. Previous affiliations of Heather Valentine include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A.
Joseph P. Steiner,Maureen Connolly,Heather Valentine,Gregory S. Hamilton,Ted M. Dawson,Lynda D. Hester,Solomon H. Snyder +6 more
TL;DR: The striking potency of these agents, their bioavailability and the dissociation of neurotrophic from immunosuppressant actions argue for their therapeutic relevance in the treatment of neurodegenerative diseases.
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Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models
Joseph P. Steiner,Gregory S. Hamilton,Douglas T. Ross,Heather Valentine,Hongzhi Guo,Maureen Connolly,Shi Liang,Cynthia Ramsey,Jia He J. Li,Huang Wei,Pamela Howorth,Rajat Soni,Michael D Fuller,Hans Sauer,Alison C. Nowotnik,Peter D. Suzdak +15 more
TL;DR: In the central nervous system, GPI-1046 promoted protection and/or sprouting of serotonin-containing nerve fibers in somatosensory cortex following parachloroamphetamine treatment and induced regenerative sprouting from spared nigrostriatal dopaminergic neurons following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in mice or 6-hydroxydopamine toxicity in rats.
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Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)
Andrew G. Horti,Yongjun Gao,Hayden T. Ravert,Paige Finley,Heather Valentine,Dean F. Wong,Christopher J. Endres,Alena Savonenko,Robert F. Dannals +8 more
TL;DR: The radiosynthesis of [11C]A-836339 via its desmethyl precursor as a candidate radioligand for imaging CB2 receptors with positron-emission tomography (PET) establishes a proof of principle thatCB2 receptors binding in the neuro inflammation and related disorders can be measured in vivo.
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Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer’s Disease with Positron Emission Tomography
Luca Gobbi,Henner Knust,Matthias Körner,Michael Honer,Christian Czech,Sara Belli,Dieter Muri,Martin R. Edelmann,Thomas Hartung,Isabella Erbsmehl,Sandra Grall-Ulsemer,Andreas Koblet,Marianne Rueher,Sandra Steiner,Hayden T. Ravert,William B. Mathews,Daniel P. Holt,Hiroto Kuwabara,Heather Valentine,Robert F. Dannals,Dean F. Wong,Edilio Borroni +21 more
TL;DR: Three novel PET tracers are discovered with high affinity for tau neurofibrillary tangles, excellent selectivity against Aβ plaques, and appropriate pharmacokinetic and metabolic properties in mice and non-human primates.
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Human brain imaging of α7 nAChR with [(18)F]ASEM: a new PET radiotracer for neuropsychiatry and determination of drug occupancy.
Dean F. Wong,Hiroto Kuwabara,Martin G. Pomper,Daniel P. Holt,James Robert Brašić,Noble George,Boris Frolov,William Willis,Yongjun Gao,Heather Valentine,Ayon Nandi,Lorena Gapasin,Robert F. Dannals,Andrew G. Horti +13 more
TL;DR: The characteristics of [18F]ASEM are consistent with the ability to quantify α7-nAChR in the human brain and is suitable for imaging neuropsychiatric disorders and target engagement (receptor occupancy) of potential α 7-n AChR drugs.