Heba I. Diab

TL;DR: The identification of transcription factor E3 (TFE3) as another regulator of lysosomal homeostasis that induced expression of genes encoding proteins involved in autophagy and lYSosomal biogenesis in ARPE-19 cells in response to starvation and lysOSomal stress is reported.

TL;DR: It is determined that TFEB and TFE3 collaborate with each other in activated macrophages and microglia to promote efficient autophagy induction, increased lysosomal biogenesis, and transcriptional upregulation of numerous proinflammatory cytokines.

TL;DR: Under conditions of prolonged ER stress, TFEB and TFE3 contribute to cell death, thus revealing an unexpected role for these proteins in controlling cell fate.

TL;DR: The characterization of this fascinating family of transcription factors is greatly expanding the understanding of how cells synchronize environmental signals, such as nutrient availability, with gene expression, energy production, and cellular homeostasis.

TL;DR: This work performed global RNA transcript analysis and comprehensive gene group analysis of peripheral blood leukocyte (PBL) RNA from two groups of matched sib‐pairs that were discordant for either schizophrenia or bipolar disorder to provide compelling evidence for the utility of analyzing PBL RNA for changes in expression in neuropsychiatric disorders.