H
Hein Stam
Researcher at DSM
Publications - 33
Citations - 2717
Hein Stam is an academic researcher from DSM. The author has contributed to research in topics: Aspergillus niger & Gene. The author has an hindex of 18, co-authored 33 publications receiving 2545 citations.
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Journal ArticleDOI
Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
Herman Jan Pel,Johannes H. de Winde,Johannes H. de Winde,David B. Archer,Paul S. Dyer,Gerald Hofmann,Peter J. Schaap,Geoffrey Turner,Ronald P. de Vries,Richard Albang,Kaj Albermann,Mikael Rørdam Andersen,Jannick Dyrløv Bendtsen,Jacques A.E. Benen,Marco A. van den Berg,Stefaan Breestraat,Mark X. Caddick,Roland Contreras,Michael Cornell,Pedro M. Coutinho,Etienne Danchin,Alfons J. M. Debets,Peter J. T. Dekker,Piet W.M. van Dijck,Alard Van Dijk,Lubbert Dijkhuizen,Arnold J. M. Driessen,Christophe d'Enfert,Steven Geysens,Coenie Goosen,Gert S.P. Groot,Piet W. J. de Groot,Thomas Guillemette,Bernard Henrissat,Marga Herweijer,Johannes Petrus Theodorus Wilhelmus Van Den Hombergh,Cees A. M. J. J. van den Hondel,René T. J. M. van der Heijden,Rachel M. van der Kaaij,Frans M. Klis,Harrie J. Kools,Christian P. Kubicek,Patricia Ann van Kuyk,Jürgen Lauber,Xin Lu,Marc J. E. C. van der Maarel,Rogier Meulenberg,Hildegard Henna Menke,Martin Mortimer,Jens Nielsen,Stephen G. Oliver,Maurien M.A. Olsthoorn,K. Pal,K. Pal,Noël Nicolaas Maria Elisabeth Van Peij,Arthur F. J. Ram,Ursula Rinas,Johannes Andries Roubos,Cornelis Maria Jacobus Sagt,Monika Schmoll,Jibin Sun,David W. Ussery,János Varga,Wouter Vervecken,Peter J.J. Van De Vondervoort,Holger Wedler,Han A. B. Wösten,An-Ping Zeng,Albert J. J. van Ooyen,Jaap Visser,Hein Stam +70 more
TL;DR: The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid, and the sequenced genome revealed a large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors.
Journal ArticleDOI
Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015 versus enzyme-producing CBS 513.88
Mikael Rørdam Andersen,Margarita Salazar,Peter J. Schaap,Peter J. I. van de Vondervoort,David E. Culley,Jette Thykaer,Jens Christian Frisvad,Kristian Fog Nielsen,Richard Albang,Kaj Albermann,Randy M. Berka,Gerhard H. Braus,Susanna A. Braus-Stromeyer,Luis M. Corrochano,Ziyu Dai,Piet W.M. van Dijck,Gerald Hofmann,Linda L. Lasure,Jon K. Magnuson,Hildegard Henna Menke,M. Meijer,Susan Lisette Meijer,Jakob Blæsbjerg Nielsen,Michael Lynge Nielsen,Albert J. J. van Ooyen,Herman Jan Pel,Lars Kongsbak Poulsen,Rob Samson,Hein Stam,Adrian Tsang,Johannes Maarten Van Den Brink,Alex Atkins,Andrea Aerts,Harris Shapiro,Jasmyn Pangilinan,Asaf Salamov,Yigong Lou,Erika Lindquist,Susan Lucas,Jane Grimwood,Igor V. Grigoriev,Christian P. Kubicek,Diego Martinez,Noël Nicolaas Maria Elisabeth Van Peij,Johannes Andries Roubos,Jens Nielsen,Scott E. Baker +46 more
TL;DR: In this article, the authors performed whole-genome sequencing of the Aspergillus niger wild-type strain (ATCC 1015) and produced a genome sequence of very high quality.
Comparative genomics of citric-acid producing Aspergillus niger ATCC 1015 versus enzyme-producing CBS 513.88 [working title: Aspergillus niger strain evolution]
Susan Lucas,Igor V. Grigoriev,Harris Shapiro,Andrea Aerts,Alex Atkins,Asaf Salamov,Erika Lindquist,Jasmyn Pangilinan,Yunian Lou,Jane Grimwood,Mikael Rørdam Andersen,Margarita Salazar,Peter J. Schaap,P de Vondervoot,David E. Culley,Scott E. Baker,Jette Thykaer,Jens Christian Frisvad,Kristian Fog Nielsen,Richard Albang,Kaj Albermann,Randy M. Berka,Gerhard H. Braus,Susanna A. Braus-Stromeyer,Luis M. Corrochano,Ziyu Dai,P van Dijck,Gerald Hofmann,Linda L. Lasure,J Magnusson,Susan Lisette Meijer,Jens Nielsen,Michael Lynge Nielsen,A van Ooyen,K Panther,Herman Jan Pel,Lars Kongsbak Poulsen,Rob Samson,Hein Stam,Adrian Tsang,J den Brink,Christian P. Kubicek,Diego Martinez,N van Peij,Johannes Andries Roubos +44 more
TL;DR: In this paper, the authors performed whole-genome sequencing of the Aspergillus niger wild-type strain (ATCC 1015) and produced a genome sequence of very high quality.
Journal ArticleDOI
Genomic analysis of the secretion stress response in the enzyme-producing cell factory Aspergillus niger
Thomas Guillemette,Thomas Guillemette,Noël Nicolaas Maria Elisabeth Van Peij,Theo Goosen,Karin Lanthaler,Geoffrey D. Robson,Cees A. M. J. J. van den Hondel,Hein Stam,David B. Archer +8 more
TL;DR: Insight has been gained into the molecular basis of protein secretion and secretion-related stress in an effective protein-secreting fungus, and provides an opportunity to identify target genes for manipulation in strain improvement strategies.