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Hela Al-Merie

Bio: Hela Al-Merie is an academic researcher from Jordan University of Science and Technology. The author has contributed to research in topics: Carbon tetrachloride & Pistacia. The author has an hindex of 2, co-authored 2 publications receiving 146 citations.

Papers
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Journal ArticleDOI
TL;DR: Aqueous extract of Pistacia lentiscus (both boiled and non-boiled) showed marked antihepatotoxic activity against CCl(4) by reducing the activity of the three enzymes and the level of bilirubin.

96 citations

Journal ArticleDOI
TL;DR: The optimum intraperitoneal dose of CCl(4) was found to be 2 ml/kg body weight (dissolved in an equal volume of olive oil), and this increased the level of bilirubin and the activity of the three enzymes significantly, without causing death of the animals.

59 citations


Cited by
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Journal ArticleDOI
TL;DR: Results of the present study showed that MSC have a potential therapeutic effect against the fibrotic process through their effect in minimizing collagen deposition in addition to their capacity to differentiate into hepatocytes.

289 citations

Journal ArticleDOI
TL;DR: The present review summarizes comprehensive information concerning ethnomedicinal uses, phytochemistry, and pharmacological activities of the five mentioned Pistacia species.
Abstract: Pistacia, a genus of flowering plants from the family Anacardiaceae, contains about twenty species, among them five are more popular including P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus. Different parts of these species have been used in traditional medicine for various purposes like tonic, aphrodisiac, antiseptic, antihypertensive and management of dental, gastrointestinal, liver, urinary tract, and respiratory tract disorders. Scientific findings also revealed the wide pharmacological activities from various parts of these species, such as antioxidant, antimicrobial, antiviral, anticholinesterase, anti-inflammatory, antinociceptive, antidiabetic, antitumor, antihyperlipidemic, antiatherosclerotic, and hepatoprotective activities and also their beneficial effects in gastrointestinal disorders. Various types of phytochemical constituents like terpenoids, phenolic compounds, fatty acids, and sterols have also been isolated and identified from different parts of Pistacia species. The present review summarizes comprehensive information concerning ethnomedicinal uses, phytochemistry, and pharmacological activities of the five mentioned Pistacia species.

248 citations

Journal ArticleDOI
TL;DR: The present work constitutes a review of the literature on plant extracts and chemically defined molecules of natural origin with hepatoprotective activity and intends to aid researchers in the study of natural products useful in the treatment of liver diseases.
Abstract: Liver diseases are a major worldwide health problem, with high endemicity in developing countries. They are mainly caused by chemicals and some drugs when taken in very high doses. Despite advances in modern medicine, there is no effective drug available that stimulates liver function, offer protection to the liver from damage or help to regenerate hepatic cells. There is urgent need, therefore, for effective drugs to replace/supplement those in current use. The plant kingdom is undoubtedly valuable as a source of new medicinal agents. The present work constitutes a review of the literature on plant extracts and chemically defined molecules of natural origin with hepatoprotective activity. The review shows 107 plants, their families, geographical distribution, plant parts utilized, type of assay and inducer of liver damage. It also includes 58 compounds isolated from higher plants, classified into appropriate chemical groups. This work intends to aid researchers in the study of natural products useful in the treatment of liver diseases. Key words: Liver, liver disease, hepatoprotective activity, natural products.

163 citations

Journal ArticleDOI
TL;DR: A systematic review of both the state of the art of traditional Arab herbal medicine and the status of the know-how of Arab herbalists is presented.
Abstract: Historical and current studies indicate that the Eastern region of the Mediterranean has been distinguished from other regions by a rich inventory of complementary alternative medicine (CAM), in particular herbal medicine. Data collected from several surveys and studies indicate that there is a flourishing and well-developed trade of herbs. These surveys also reveal that 200–250 herbs are used in treating human diseases and are sold or traded in market places in the Mediterranean region or internationally. In addition, some of these herbs are rare or even endangered species. In regard to the status of the know-how of herbalists, unfortunately, herbal medicine in our region is mostly prescribed by ethnopharmacologists symptomatically—based on signs and symptoms alone, rather than as a result of a full understanding of the underlying disease. In some cases, herbs used today may not even correspond to the plants described originally in the old literature, as the former are cultivated from herbs that went through different breeding procedures throughout several centuries. This article presents a systematic review of both the state of the art of traditional Arab herbal medicine and the status of the know-how of Arab herbalists.

153 citations

Journal ArticleDOI
TL;DR: Results clearly demonstrate that D. muricata treatment augments the antioxidants defense mechanism against carbon tetrachloride induced toxicity and provides evidence that it may have a therapeutic role in free radical mediated diseases.

148 citations