H
Helena Couto Junqueira
Researcher at University of São Paulo
Publications - 31
Citations - 1873
Helena Couto Junqueira is an academic researcher from University of São Paulo. The author has contributed to research in topics: Singlet oxygen & Photosensitizer. The author has an hindex of 14, co-authored 27 publications receiving 1474 citations.
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Journal ArticleDOI
Methylene blue in photodynamic therapy: From basic mechanisms to clinical applications.
João Paulo Tardivo,Auro Del Giglio,Carla Santos de Oliveira,Dino Santesso Gabrielli,Helena Couto Junqueira,Dayane Batista Tada,Divinomar Severino,R. F. Turchiello,Mauricio S. Baptista +8 more
TL;DR: It is concluded that used together with a recently developed continuous light source (RL50(®)), MB has the potential to treat a variety of cancerous and non-cancerous diseases, with low toxicity and no side effects.
Journal ArticleDOI
Modulation of methylene blue photochemical properties based on adsorption at aqueous micelle interfaces
Helena Couto Junqueira,Divinomar Severino,Luís G. Dias,Marcos Gugliotti,Mauricio S. Baptista +4 more
TL;DR: In this article, the photochemical properties of methylene blue (MB+) were studied in CTAB and Cetyl trimethylammonium bromide (CTAB) solutions.
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Influence of Negatively Charged Interfaces on the Ground and Excited State Properties of Methylene Blue
Divinomar Severino,Helena Couto Junqueira,Marcos Gugliotti,Dino Santesso Gabrielli,Mauricio S. Baptista +4 more
TL;DR: Differences in the fluorescence intensity as a function of dimer–monomer ratio as well as in the resonance light scattering spectra indicate that distinct types of dimers are induced in sodium dodecyl sulfate micelles and aerosol-OT (sodium dioctyl sulfoxinate, AOT) reversed micells.
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Photosensitized Membrane Permeabilization Requires Contact-Dependent Reactions between Photosensitizer and Lipids.
Isabel O. L. Bacellar,Isabel O. L. Bacellar,Maria Cecilia Oliveira,Lucas S. Dantas,Elierge B. Costa,Helena Couto Junqueira,Waleska Kerllen Martins,Andrés M. Durantini,Gonzalo Cosa,Paolo Di Mascio,Mark Wainwright,Ronei Miotto,Rodrigo M. Cordeiro,Sayuri Miyamoto,Mauricio S. Baptista +14 more
TL;DR: Processes depending on direct contact between photosensitizers and lipids were revealed to be essential for the progress of lipid oxidation and consequently for aldehyde formation, providing a molecular-level explanation of why membrane binding correlates so well with the cell-killing efficiency of photosenitizers.
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Membrane changes under oxidative stress: the impact of oxidized lipids.
TL;DR: The giant unilamellar vesicle is used as a simplified model of biological membranes to investigate how in situ photogenerated oxidative species impact the phospholipid bilayer and provides a new tool to explore membrane response to an oxidative stress.