H
Helena I. Boshoff
Researcher at National Institutes of Health
Publications - 174
Citations - 11986
Helena I. Boshoff is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 49, co-authored 163 publications receiving 10359 citations. Previous affiliations of Helena I. Boshoff include St. Jude Children's Research Hospital & National Health Laboratory Service.
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Journal ArticleDOI
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
Clifton E. Barry,Helena I. Boshoff,Véronique Dartois,Thomas Dick,Sabine Ehrt,JoAnne L. Flynn,Dirk Schnappinger,Robert J. Wilkinson,Robert J. Wilkinson,Robert J. Wilkinson,Douglas B. Young,Douglas B. Young +11 more
TL;DR: The biology of latent tuberculosis is discussed as part of a broad range of responses that occur following infection with Mycobacterium tuberculosis, which result in the formation of physiologically distinct granulomatous lesions that provide microenvironments with differential ability to support or suppress the persistence of viable bacteria.
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The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action.
Helena I. Boshoff,Timothy G. Myers,Brent R. Copp,Michael R. McNeil,Michael A Wilson,Clifton E. Barry +5 more
TL;DR: The transcriptional profile generated by a crude marine natural product recapitulated the mechanistic prediction from the pure active component of Mycobacterium tuberculosis and provide a rational basis for the selection of critical metabolic targets for screening for new agents with improved activity against this important human pathogen.
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PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release
Ramandeep Singh,Ujjini H. Manjunatha,Ujjini H. Manjunatha,Helena I. Boshoff,Young Hwan Ha,Pornwaratt Niyomrattanakit,Richard Ledwidge,Cynthia S. Dowd,Ill Young Lee,Pilho Kim,Liang Zhang,Sunhee Kang,Thomas H. Keller,Jan Jiricek,Clifton E. Barry +14 more
TL;DR: It is found that Rv3547 is a deazaflavin-dependent nitroreductase (Ddn) that converts PA-824 into three primary metabolites; the major one is the corresponding des-nitroimidazole (des-Nitro).
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Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis
TL;DR: When meropenem was combined with the β-lactamase inhibitor clavulanate, potent activity against laboratory strains of M. tuberculosis was observed and could potentially be used to treat patients with currently untreatable disease.
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Tuberculosis — metabolism and respiration in the absence of growth
TL;DR: Transcriptomics and studies using bacterial mutants have led to testable hypotheses about metabolic functions that are essential for viability in the absence of replication.