Hendrik Marks

TL;DR: It is suggested that transcriptional potentiation and a permissive chromatin context characterize the ground state and that exit from it may not require a metastable intermediate or multilineage priming.

TL;DR: The authors' data reveal a highly adapted interplay between chromatin marks and their associated protein complexes, and reading specific trimethyl-lysine sites by specialized complexes appears to be a widespread mechanism to mediate gene expression.

TL;DR: WGBS analysis during adaptation of 2i ESCs to serum suggests that deposition ofDNA methylation is largely random, while loss of DNA methylation during reversion to 2i occurs passively, initiating at TET1 binding sites.

TL;DR: ChIP-bisulfite-sequencing was used in this article to quantitatively assess DNA methylation patterns associated with chromatin modifications or chromatin-associated factors directly, and the results showed that H3K27me3 and DNA are compatible throughout most of the genome, except for CpG islands, where these two marks are mutually exclusive.

TL;DR: It is shown that Mll2, one of the six Set1/Trithorax-type H3K4 methyltransferases in mammals, is required for trimethylation of bivalent promoters in mouse embryonic stem cells and proposed that MLL2 is the pioneer trimethyltransferase for promoter definition in the naïve epigenome and that Polycomb group action on bivalent promoter blocks the premature establishment of active, Set1C-bound, promoters.