H
Heng-Yu Fan
Researcher at Life Sciences Institute
Publications - 141
Citations - 6647
Heng-Yu Fan is an academic researcher from Life Sciences Institute. The author has contributed to research in topics: Oocyte & Germinal vesicle. The author has an hindex of 42, co-authored 125 publications receiving 5243 citations. Previous affiliations of Heng-Yu Fan include Baylor College of Medicine & Zhejiang University.
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Journal ArticleDOI
MAPK3/1 (ERK1/2) in Ovarian Granulosa Cells Are Essential for Female Fertility
Heng-Yu Fan,Zhilin Liu,Masayuki Shimada,Esta Sterneck,Peter F. Johnson,Stephen M. Hedrick,JoAnne S. Richards +6 more
TL;DR: Targeted disruption of the kinases ERK1 and ERK2 in mouse granulosa cells provides in vivo evidence that these kinases are necessary for LH-induced oocyte resumption of meiosis, ovulation, and luteinization-related events.
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Involvement of Mitogen-Activated Protein Kinase Cascade During Oocyte Maturation and Fertilization in Mammals
TL;DR: Mitogen-activated protein kinase (MAPK) is a family of Ser/Thr protein kinases that are widely distributed in eukaryotic cells that plays pivotal roles in regulating the meiotic cell cycle progression of oocytes.
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Follicle-stimulating hormone induces multiple signaling cascades: evidence that activation of Rous sarcoma oncogene, RAS, and the epidermal growth factor receptor are critical for granulosa cell differentiation.
TL;DR: It is shown that FSH induces AREG and that activation of the EGFR impacts granulosa cell differentiation and the expression of genes characteristic of the luteal cell phenotype.
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BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes
Chao Yu,Shu-Yan Ji,Qian-Qian Sha,Yujiao Dang,Jian-Jie Zhou,Yin-Li Zhang,Yang Liu,Zhong-Wei Wang,Boqiang Hu,Qing-Yuan Sun,Shao-Chen Sun,Fuchou Tang,Heng-Yu Fan +12 more
TL;DR: B-cell translocation gene-4 (BTG4) is identified as an MZT licensing factor in mice and triggered translation of Btg4 mRNA stored in fully grown oocytes by targeting the 3′ untranslated region, thereby coupling CCR4–NOT deadenylase–mediated decay of maternal mRNA with oocyte maturation and fertilization.
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High salt primes a specific activation state of macrophages, M(Na)
Wu-Chang Zhang,Xiao-Jun Zheng,Lin-Juan Du,Jian-Yong Sun,Zhu-Xia Shen,Chaoji Shi,Shuyang Sun,Zhiyuan Zhang,Xiao-Qing Chen,Mu Qin,Xu Liu,Jun Tao,Lijun Jia,Heng-Yu Fan,Bin（周斌） Zhou,Ying（余鹰） Yu,Hao（应浩） Ying,Lijian Hui,Xiaolong Liu,Xianghua Yi,Xiaojing Liu,Lanjing Zhang,ShengZhong（段胜仲） Duan +22 more
TL;DR: It is shown that high salt increased proinflammatory molecules, while decreased anti-inflammatory and proendocytic molecules in both human and mouse macrophages, and is identified as a potential environmental risk factor for lung inflammation through the induction of M(Na).