Author
Henricus J. C. M. Sterenborg
Other affiliations: University College Hospital, University of Texas Medical Branch, University College London ...read more
Bio: Henricus J. C. M. Sterenborg is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Autofluorescence & Scattering. The author has an hindex of 52, co-authored 243 publications receiving 10188 citations. Previous affiliations of Henricus J. C. M. Sterenborg include University College Hospital & University of Texas Medical Branch.
Papers published on a yearly basis
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Journal Article•
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TL;DR: The absorption and scattering data show that for all wavelengths considered, scattering is much more important than absorption, and any quantitative dosimetry for skin treated with (laser) light is inaccurate.
Abstract: The current status of tissue optics is reviewed, distinguishing among the cases of dominant absorption, dominant scattering, and scattering about equal to absorption. Previously published data as well as some current unpublished data on (human) stratum corneum, epidermis, and dermis are collected and/or (re)analyzed in terms of absorption coefficient, scattering coefficient, and anisotropy scattering factor. It is found that the individual skin layers show strongly forward scattering (anisotropy factors between 0.7 and 0.9). The absorption and scattering data show that for all wavelengths considered, scattering is much more important than absorption. Solutions to the transport equation for a multilayer skin model and finite beam laser irradiation that take this into account are not yet available. Hence, any quantitative dosimetry for skin treated with (laser) light is inaccurate. >
804 citations
TL;DR: A system synthesizes the theory of two integrating spheres and an intervening scattering sample with the inverse adding-doubling algorithm to determine the optical properties from the measurement of the light flux within each sphere and of the unscattered transmission.
Abstract: A system is described and evaluated for the simultaneous measurement of the intrinsic optical properties of tissue: the scattering coefficient, the absorption coefficient, and the anisotropy factor. This system synthesizes the theory of two integrating spheres and an intervening scattering sample with the inverse adding–doubling algorithm, which employs the adding–doubling solution of the radiative transfer equation to determine the optical properties from the measurement of the light flux within each sphere and of the unscattered transmission. The optical properties may be determined simultaneously, which allows for measurements to be made while the sample undergoes heating, chemical change, or some other external stimulus. An experimental validation of the system with tissue phantoms resulted in the determination of the optical properties with a <5% deviation when the optical density was between 1 and 10 and the albedo was between 0.4 and 0.95.
477 citations
Journal Article•
TL;DR: The large variation in tumor responses in the present data set can be transformed to a coherent, common dose-response relationship by proper spectral weighting with this single action spectrum.
Abstract: Information on the variation in carcinogenicity with wavelength is crucial in risk assessments for skin cancers induced by UV radiation. Until recently the wavelength (lambda) dependencies of other detrimental UV effects, such as sunburn, have been used as substitutes. Direct information on the lambda dependency can only be obtained from animal experiments. To this end we accumulated a large data set on skin tumors induced by chronic UV exposure of albino SKH:HR1 mice (14 different broadband UV sources and about 1100 mice); the data come from the Photobiology Unit of the former Skin and Cancer Hospital in Philadelphia and from the Department of Dermatology of the University of Utrecht. The lambda dependency was extracted from this data set (a statistically satisfactory description with chi 2 = 13.4, df = 7) and represented by the Skin Cancer Utrecht-Philadelphia action spectrum, i.e., a set of factors to weight the exposures at different wavelengths according to their respective effectiveness (inversely proportional to the daily exposure required for a median tumor induction time of 300 days). The fits obtained with other already available action spectra proved to be poor (chi 2 > 60, df = 11). The maximum effectiveness was found at 293 nm, and above 340 nm the effectiveness showed a shoulder at about 10(-4) of the maximum. A sensitivity analysis of the final solution for the lambda dependency showed a large margin of uncertainty above 340 nm and an information gap below 280 nm. The large variation in tumor responses in the present data set can be transformed to a coherent, common dose-response relationship by proper spectral weighting with this single action spectrum.
472 citations
TL;DR: In this paper, a method is described for measuring optical properties and deriving chromophore concentrations from diffuse reflection measurements at the surface of a turbid medium using diffusion approximation model for the diffuse reflectance, in combination with models for the absorption and scattering coefficients.
Abstract: A method is described for measuring optical properties and deriving chromophore concentrations from diffuse reflection measurements at the surface of a turbid medium. The method uses a diffusion approximation model for the diffuse reflectance, in combination with models for the absorption and scattering coefficients. An optical fibre-based set-up, capable of measuring nine spectra from 400 to 1050 nm simultaneously, is used to test the method experimentally. Results of the analyses of phantom and in vivo measurements are presented. These demonstrate that in the wavelength range from 600 to 900 nm, tissue scattering can be described as a simple power dependence of the wavelength and that the tissue absorption can be accurately described by the addition of water, oxy- and deoxyhaemoglobin absorption.
429 citations
TL;DR: It is hoped that from the studies performed so far whether autofluorescence spectroscopy and imaging are helpful in the diagnosis of lesions of the oral mucosa, and if this is the case: for which clinical questions they are suitable.
265 citations
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TL;DR: A review of reported tissue optical properties summarizes the wavelength-dependent behavior of scattering and absorption in cells and tissues.
Abstract: A review of reported tissue optical properties summarizes the wavelength-dependent behavior of scattering and absorption. Formulae are presented for generating the optical properties of a generic tissue with variable amounts of absorbing chromophores (blood, water, melanin, fat, yellow pigments) and a variable balance between small-scale scatterers and large-scale scatterers in the ultrastructures of cells and tissues.
2,920 citations
TL;DR: The known optical properties (absorption, scattering, total attenuation, effective attenuation and/or anisotropy coefficients) of various biological tissues at a variety of wavelengths are reviewed in this article.
Abstract: The known optical properties (absorption, scattering, total attenuation, effective attenuation, and/or anisotropy coefficients) of various biological tissues at a variety of wavelengths are reviewed. The theoretical foundations for most experimental approaches are outlined. Relations between Kubelka-Munk parameters and transport coefficients are listed. The optical properties of aorta, liver, and muscle at 633 nm are discussed in detail. An extensive bibliography is provided. >
2,858 citations
TL;DR: This paper presents a meta-modelling study of the response of the immune system to chemotherapy and its applications in the context of central nervous system disorders.
Abstract: Sasidharan Swarnalatha Lucky,†,§ Khee Chee Soo,‡ and Yong Zhang*,†,§,∥ †NUS Graduate School for Integrative Sciences & Engineering (NGS), National University of Singapore, Singapore, Singapore 117456 ‡Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore 169610 Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore, Singapore 117576 College of Chemistry and Life Sciences, Zhejiang Normal University, Zhejiang, P. R. China 321004
2,194 citations
TL;DR: The guidelines for the diagnosis, surveillance and therapy of Barrett’s esophagus were originally published by the American College of Gastroenterology in 1998 and updated in 2002 and once again reviewed using the National Library of Medicine database.
2,044 citations