H
Henrik Failmezger
Researcher at Institute of Cancer Research
Publications - 18
Citations - 1314
Henrik Failmezger is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 10, co-authored 17 publications receiving 1082 citations. Previous affiliations of Henrik Failmezger include Max Planck Society & Center for Integrated Protein Science Munich.
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Journal ArticleDOI
Quantitative Image Analysis of Cellular Heterogeneity in Breast Tumors Complements Genomic Profiling
Yinyin Yuan,Henrik Failmezger,Henrik Failmezger,Oscar M. Rueda,H. Raza Ali,Stefan Gräf,Suet-Feung Chin,Roland F. Schwarz,Christina Curtis,Mark J Dunning,Helen Bardwell,Nicola Johnson,Sarah Doyle,Gulisa Turashvili,Elena Provenzano,Samuel Aparicio,Carlos Caldas,Florian Markowetz +17 more
TL;DR: A predictor for survival in estrogen receptor–negative breast cancer that integrated both image-based and gene expression analyses and significantly outperformed classifiers that use single data types, such as microarray expression signatures is devised.
Supplementary Materials for Quantitative Image Analysis of Cellular Heterogeneity in Breast Tumors Complements Genomic Profiling
Yinyin Yuan,Henrik Failmezger,Oscar M. Rueda,H. Raza Ali,Stefan Gräf,Roland F. Schwarz,Christina Curtis,Mark J Dunning,Helen Bardwell,Sarah Doyle,Samuel Aparicio,Carlos Caldas,Florian Markowetz +12 more
TL;DR: Yuan et al. as discussed by the authors developed a computational approach based on standard hematoxylin and eosin-stained tissue sections and demonstrated its power in a discovery and validation cohort of 323 and 241 breast tumors, respectively.
Journal ArticleDOI
Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer
Allen W. Zhang,Andrew McPherson,Katy Milne,David R. Kroeger,Phineas T. Hamilton,Alex Miranda,Tyler Funnell,Nicole S. Little,Camila P. E. de Souza,Sonya Laan,Stacey Ledoux,Dawn R. Cochrane,Jamie L. P. Lim,Winnie Yang,Andrew Roth,Andrew Roth,Maia A. Smith,Julie Ho,Kane Tse,Thomas Zeng,Inna Shlafman,Michael Mayo,Richard D. Moore,Henrik Failmezger,Andreas Heindl,Yi Kan Wang,Ali Bashashati,Diljot Grewal,Scott D. Brown,Daniel Lai,Adrian Wan,Cydney B. Nielsen,Curtis Huebner,Basile Tessier-Cloutier,Michael S. Anglesio,Alexandre Bouchard-Côté,Yinyin Yuan,Wyeth W. Wasserman,C. Blake Gilks,Anthony N. Karnezis,Samuel Aparicio,Jessica N. McAlpine,David G. Huntsman,Robert A. Holt,Brad H. Nelson,Brad H. Nelson,Sohrab P. Shah +46 more
TL;DR: It is concluded that within-patient spatial immune microenvironment variation shapes intraperitoneal malignant spread, provoking new evolutionary perspectives on HGSC clonal dispersion.
Journal ArticleDOI
Global analysis of eukaryotic mRNA degradation reveals Xrn1-dependent buffering of transcript levels.
Mai Sun,Björn Schwalb,Nicole Pirkl,Kerstin C. Maier,Arne Schenk,Henrik Failmezger,Achim Tresch,Patrick Cramer +7 more
TL;DR: It is shown that buffering of mRNA levels requires the RNA exonuclease Xrn1, and cluster analysis of the data defines the general mRNA degradation machinery, reveals different substrate preferences for the two mRNA deadenylase complexes Ccr4-Not and Pan2-Pan3, and unveils an interwoven cellular mRNA surveillance network.
Journal ArticleDOI
Topological Tumor Graphs: A Graph-Based Spatial Model to Infer Stromal Recruitment for Immunosuppression in Melanoma Histology
Henrik Failmezger,Sathya Muralidhar,Antonio Rullan,Antonio Rullan,Carlos E. de Andrea,Erik Sahai,Yinyin Yuan +6 more
TL;DR: The genomic basis of these TTG-derived stromal phenotypes was explored using a deep learning approach integrating genomic and transcriptomic data, thereby inferring a compressed representation of copy number-driven alterations in gene expression.