H
Henry A. Erlich
Researcher at Children's Hospital Oakland Research Institute
Publications - 354
Citations - 41633
Henry A. Erlich is an academic researcher from Children's Hospital Oakland Research Institute. The author has contributed to research in topics: Human leukocyte antigen & Haplotype. The author has an hindex of 93, co-authored 354 publications receiving 40295 citations. Previous affiliations of Henry A. Erlich include Children's Hospital Oakland & University of Oxford.
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Process for amplifying, detecting, and/or-cloning nucleic acid sequences
Kary Banks Mullis,Norman Arnheim,Randall K. Saiki,Henry A. Erlich,Glenn Thomas Horn,Stephen J. Scharf +5 more
TL;DR: In this paper, the authors proposed a method for synthesizing nucleic acid sequences using primers, which can be repeated stepwise or simultaneously and can be replicated as often as desired.
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Specific Enzymatic Amplification of DNA In Vitro: The Polymerase Chain Reaction
Kary B. Mullis,Fred A. Faloona,Stephen J. Scharf,Randall Keichi Saiki,Glenn Thomas Horn,Henry A. Erlich +5 more
TL;DR: An alternative method for the synthesis of specific DNA sequences is explored that involves the reciprocal interaction of two oligonucleotides and the DNA polymerase extension products whose synthesis they prime, when they are hybridized to different strands of a DNA template in a relative orientation such that their extension products overlap.
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Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus
TL;DR: This work has studied the allelic diversity at the HLA-DQA locus and its association with the serologically defined Hla-DR and -DQ types and revealed eight alleles and three additional haplotypes.
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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Jeffrey C. Barrett,David Clayton,Patrick Concannon,Beena Akolkar,Jason D. Cooper,Henry A. Erlich,Cécile Julier,Grant Morahan,Jørn Nerup,Concepcion Nierras,Vincent Plagnol,Flemming Pociot,Helen Schuilenburg,Deborah J. Smyth,Helen Stevens,John A. Todd,Neil Walker,Stephen S. Rich +17 more
TL;DR: The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.
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Genetic analysis of amplified DNA with immobilized sequence-specific oligonucleotide probes
TL;DR: A method by which one can simultaneously screen a sample for all known allelic variants at an amplified locus is described, applied to HLA-DQA genotyping and to the detection of Mediterranean beta-thalassemia mutations.