抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Machine Learning is the study of methods for programming computers to learn. Computers are applied to a wide range of tasks, and for most of these it is relatively easy for programmers to design and implement the necessary software. However, there are many tasks for which this is difficult or impossible. These can be divided into four general categories. First, there are problems for which there exist no human experts. For example, in modern automated manufacturing facilities, there is a need to predict machine failures before they occur by analyzing sensor readings. Because the machines are new, there are no human experts who can be interviewed by a programmer to provide the knowledge necessary to build a computer system. A machine learning system can study recorded data and subsequent machine failures and learn prediction rules. Second, there are problems where human experts exist, but where they are unable to explain their expertise. This is the case in many perceptual tasks, such as speech recognition, hand-writing recognition, and natural language understanding. Virtually all humans exhibit expert-level abilities on these tasks, but none of them can describe the detailed steps that they follow as they perform them. Fortunately, humans can provide machines with examples of the inputs and correct outputs for these tasks, so machine learning algorithms can learn to map the inputs to the outputs. Third, there are problems where phenomena are changing rapidly. In finance, for example, people would like to predict the future behavior of the stock market, of consumer purchases, or of exchange rates. These behaviors change frequently, so that even if a programmer could construct a good predictive computer program, it would need to be rewritten frequently. A learning program can relieve the programmer of this burden by constantly modifying and tuning a set of learned prediction rules. Fourth, there are applications that need to be customized for each computer user separately. Consider, for example, a program to filter unwanted electronic mail messages. Different users will need different filters. It is unreasonable to expect each user to program his or her own rules, and it is infeasible to provide every user with a software engineer to keep the rules up-to-date. A machine learning system can learn which mail messages the user rejects and maintain the filtering rules automatically. Machine learning addresses many of the same research questions as the fields of statistics, data mining, and psychology, but with differences of emphasis. Statistics focuses on understanding the phenomena that have generated the data, often with the goal of testing different hypotheses about those phenomena. Data mining seeks to find patterns in the data that are understandable by people. Psychological studies of human learning aspire to understand the mechanisms underlying the various learning behaviors exhibited by people (concept learning, skill acquisition, strategy change, etc.).

Machine learning

Deposits of clastic carbonate-dominated (calciclastic) sedimentary slope systems in the rock record have been identified mostly as linearly-consistent carbonate apron deposits, even though most ancient clastic carbonate slope deposits fit the submarine fan systems better. Calciclastic submarine fans are consequently rarely described and are poorly understood. Subsequently, very little is known especially in mud-dominated calciclastic submarine fan systems. Presented in this study are a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) that reveals a >250 m thick calciturbidite complex deposited in a calciclastic submarine fan setting. Seven facies are recognised from core and thin section characterisation and are grouped into three carbonate turbidite sequences. They include: 1) Calciturbidites, comprising mostly of highto low-density, wavy-laminated bioclast-rich facies; 2) low-density densite mudstones which are characterised by planar laminated and unlaminated muddominated facies; and 3) Calcidebrites which are muddy or hyper-concentrated debrisflow deposits occurring as poorly-sorted, chaotic, mud-supported floatstones. These

Phd by thesis

http://www.maths.qmul.ac.uk/%7Elatora/report_06.pdf

Complex networks: Structure and dynamics

I have developed "tennis elbow" from lugging this book around the past four weeks, but it is worth the pain, the effort, and the aspirin. It is also worth the (relatively speaking) bargain price. Including appendixes, this book contains 894 pages of text. The entire panorama of the neural sciences is surveyed and examined, and it is comprehensive in its scope, from genomes to social behaviors. The editors explicitly state that the book is designed as "an introductory text for students of biology, behavior, and medicine," but it is hard to imagine any audience, interested in any fragment of neuroscience at any level of sophistication, that would not enjoy this book. The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or

Principles of Neural Science

We examine the issue of determining an acceptable minimum embedding dimension by looking at the behavior of near neighbors under changes in the embedding dimension from d\ensuremath{\rightarrow}d+1. When the number of nearest neighbors arising through projection is zero in dimension ${\mathit{d}}_{\mathit{E}}$, the attractor has been unfolded in this dimension. The precise determination of ${\mathit{d}}_{\mathit{E}}$ is clouded by ``noise,'' and we examine the manner in which noise changes the determination of ${\mathit{d}}_{\mathit{E}}$. Our criterion also indicates the error one makes by choosing an embedding dimension smaller than ${\mathit{d}}_{\mathit{E}}$. This knowledge may be useful in the practical analysis of observed time series.

Determining embedding dimension for phase-space reconstruction using a geometrical construction

Regular Dynamics: Newton to Poincare KAM Theorem | Bifurcations: Routes to Chaos, Stability and Instability | Reconstruction of Phase Space: Regular and Chaotic Motions Observed Chaos | Choosing Time Delays: Chaos as an Information Source Average Mutual Information. | Choosing the Dimension of Reconstructed Phase Space | Invariants of the Motion: Global & Local Lyapunov Exponents Lorenz Model | Modeling Chaos: Local & Global Models Phase Space Models | Signal Separation: Probabilistic Cleaning 'Blind' Signal Separation | Control and Chaos: Parametric Control Examples of Control (including magnetoelastic ribbon, electric circuits, cardiac tissue) | Synchronization of Chaotic Systems: Identical or Dissimilar Systems Chaotic Nonlinear Circuits | Other Example Systems: Laser Intensity Fluctuations Volume Fluctuations of the Great Salt Lake Motion in a Fluid Boundary Layer | Estimating in Chaos: Cramer-Rao Bounds | The Chaos Toolkit: Making 'Physics' out of Chaos

https://www.springer.com/productFlyer_978-0-387-98372-1.pdf?SGWID=0-0-1297-1587867-0

Analysis of Observed Chaotic Data

Chaotic time series data are observed routinely in experiments on physical systems and in observations in the field. The authors review developments in the extraction of information of physical importance from such measurements. They discuss methods for (1) separating the signal of physical interest from contamination ("noise reduction"), (2) constructing an appropriate state space or phase space for the data in which the full structure of the strange attractor associated with the chaotic observations is unfolded, (3) evaluating invariant properties of the dynamics such as dimensions, Lyapunov exponents, and topological characteristics, and (4) model making, local and global, for prediction and other goals. They briefly touch on the effects of linearly filtering data before analyzing it as a chaotic time series. Controlling chaotic physical systems and using them to synchronize and possibly communicate between source and receiver is considered. Finally, chaos in space-time systems, that is, the dynamics of fields, is briefly considered. While much is now known about the analysis of observed temporal chaos, spatio-temporal chaotic systems pose new challenges. The emphasis throughout the review is on the tools one now has for the realistic study of measured data in laboratory and field settings. It is the goal of this review to bring these tools into general use among physicists who study classical and semiclassical systems. Much of the progress in studying chaotic systems has rested on computational tools with some underlying rigorous mathematics. Heuristic and intuitive analysis tools guided by this mathematics and realizable on existing computers constitute the core of this review.

The analysis of observed chaotic data in physical systems

Synchronization of chaotic systems is frequently taken to mean actual equality of the variables of the coupled systems as they evolve in time. We explore a generalization of this condition, which equates dynamical variables from one subsystem with a function of the variables of another subsystem. This means that synchronization implies a collapse of the overall evolution onto a subspace of the system attractor in full space. We explore this idea in systems where a response system [bold y]([ital t]) is driven with the output of a driving system [bold x]([ital t]), but there is no feedback to the driver. We lose generality but gain tractability with this restriction. To investigate the existence of the synchronization condition [bold y]([ital t])=[phi]([bold x]([ital t])) we introduce the idea of mutual false nearest neighbors to determine when closeness in response space implies closeness in driving space. The synchronization condition also implies that the response dynamics is determined by the drive alone, and we provide tests for this as well. Examples are drawn from computer simulations on various known cases of synchronization and on data from nonlinear electrical circuits. Determining the presence of generalized synchronization will be quite important when one has only scalarmore » observations from the drive and from the response systems since the use of time delay (or other) embedding methods will produce imperfect'' coordinates in which strict equality of the synchronized variables is unlikely to transpire.« less

Generalized synchronization of chaos in directionally coupled chaotic systems

This work was supported by NSF Grant No. NSF/EIA-0130708, and Grant No. PHY 0414174; NIH Grant No. 1 R01 NS50945 and Grant No. NS40110; MEC BFI2003-07276, and Fundacion BBVA.

/pdf/dynamical-principles-in-neuroscience-3b8nfk3ipm.pdf

Henry D. I. Abarbanel

Papers

Determining embedding dimension for phase-space reconstruction using a geometrical construction

Analysis of Observed Chaotic Data

The analysis of observed chaotic data in physical systems

Generalized synchronization of chaos in directionally coupled chaotic systems

Dynamical principles in neuroscience