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Showing papers by "Henry R. Black published in 1987"


Journal ArticleDOI
TL;DR: Doxazosin is an effective hypotensive agent with beneficial effects on serum lipid levels and both doxazosIn and atenolol demonstrated comparable acceptance profiles, although no statistically significant differences between the active agents were noted.
Abstract: The antihypertensive and lipid effects of doxazosin and atenolol were compared in a 10-week, double-blind, parallel, placebo-controlled study. The 129 adults enrolled had mild to moderate hypertension (average supine diastolic blood pressures for doxazosin, atenolol and placebo were 100.6, 101.0 and 99.7 mm Hg, respectively). Patients were randomly assigned to treatment with doxazosin, 1 to 16 mg daily, atenolol, 50 to 100 mg daily or placebo. Among 114 patients included in the efficacy analysis, standing blood pressure (systolic/diastolic) changed by −13 −11 mm Hg with doxazosin (n = 37), −12 −12 mm Hg with atenolol (n = 39) and +1 −1 mm Hg with placebo (n = 38). Mean reductions in blood pressure for doxazosin and atenolol were significantly greater than those for placebo (p

29 citations