Background: Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Since the American Thyroid Association's (ATA's) guidelines for the management of these disorders were revised in 2009, significant scientific advances have occurred in the field. The aim of these guidelines is to inform clinicians, patients, researchers, and health policy makers on published evidence relating to the diagnosis and management of thyroid nodules and differentiated thyroid cancer. Methods: The specific clinical questions addressed in these guidelines were based on prior versions of the guidelines, stakeholder input, and input of task force members. Task force panel members were educated on knowledge synthesis methods, including electronic database searching, review and selection of relevant citations, and critical appraisal of selected studies. Published English language articles on adults were eligible for inclusion. The American College of Physicians Guideline Gr...

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2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.

Background: Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Since the publication of the American Thyroid Association's guidelines for the management of these disorders was published in 2006, a large amount of new information has become available, prompting a revision of the guidelines. Methods: Relevant articles through December 2008 were reviewed by the task force and categorized by topic and level of evidence according to a modified schema used by the United States Preventative Services Task Force. Results: The revised guidelines for the management of thyroid nodules include recommendations regarding initial evaluation, clinical and ultrasound criteria for fine-needle aspiration biopsy, interpretation of fine-needle aspiration biopsy results, and management of benign thyroid nodules. Recommendations regarding the initial management of thyroid cancer include those relating to optimal surgical management, radioiodine remnant ablation, a...

/pdf/revised-american-thyroid-association-management-guidelines-3i6bt8nj9c.pdf

Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer

Abstract In this paper we present an International Socio-Economic Index of occupational status (ISEI), derived from the International Standard Classification of Occupations (ISCO), using comparably coded data on education, occupation, and income for 73,901 full-time employed men from 16 countries. We use an optimal scaling procedure, assigning scores to each of 271 distinct occupation categories in such a way as to maximize the role of occupation as an intervening variable between education and income (in contrast to taking prestige as the criterion for weighting education and income, as in the Duncan scale). We compare the resulting scale to two existing internationally standardized measures of occupational status, Treiman's international prestige scale (SIOPS) and Goldthorpe's class categories (EGP), and also with several locally developed SEI scales. The performance of the new ISEI scale compares favorably with these alternatives, both for the data sets used to construct the scale and for five additional data sets.

A standard international socio-economic index of occupational status

https://research.vu.nl/ws/files/87034982/1992_Ganzeboom_De_Graaf_Treiman_A_standard_international_socio_economic_index_of_occupational_status.pdf

/pdf/management-guidelines-for-patients-with-thyroid-nodules-and-33wjxjfqag.pdf

Management guidelines for patients with thyroid nodules and differentiated thyroid cancer.

This survey is a synthesis of the economic, social, cultural, and political history of the Atlantic slave trade, providing the general reader with a basic understanding of the current state of scholarly knowledge of forced African migration and compares this knowledge to popular beliefs The Atlantic Slave Trade examines the four hundred years of Atlantic slave trade, covering the West and East African experiences, as well as all the American colonies and republics that obtained slaves from Africa It outlines both the common features of this trade and the local differences that developed It discusses the slave trade's economics, politics, demographic impact, and cultural implications in relationship to Africa as well as America Finally, it places the slave trade in the context of world trade and examines the role it played in the growing relationship between Asia, Africa, Europe, and America This new edition incorporates the latest findings of the last decade in slave trade studies carried out in Europe and America It also includes new data on the slave trade voyages which have just recently been made available to the public

The Atlantic Slave Trade

This is an original survey of the economic and social history of slavery of the Afro-American experience in Latin America and the Caribbean. The focus of the book is on the Portuguese, Spanish, and French-speaking regions of continental America and the Caribbean. It analyzes the latest research on urban and rural slavery and on the African and Afro-American experience under these regimes. It approaches these themes both historically and structurally. The historical section provides a detailed analysis of the evolution of slavery and forced labor systems in Europe, Africa, and America. The second half of the book looks at the type of life and culture which the salves experienced in these American regimes. The first part of the book describes the growth of the plantation and mining economies that absorbed African slave labor, how that labor was used, and how the changing international economic conditions affected the local use and distribution of the slave labor force. Particular emphasis is given to the evolution of the sugar plantation economy, which was the single largest user of African slave labor and which was established in almost all of the Latin American colonies. Once establishing the economic context in which slave labor was applied, the book shifts focus to the Africans and Afro-Americans themselves as they passed through this slave regime. The first part deals with the demographic history of the slaves, including their experience in the Atlantic slave trade and their expectations of life in the New World. The next part deals with the attempts of the African and American born slaves to create a viable and autonomous culture. This includes their adaptation of European languages, religions, and even kinship systems to their own needs. It also examines systems of cooptation and accommodation to the slave regime, as well as the type and intensity of slave resistances and rebellions. A separate chapter is devoted to the important and different role of the free colored under slavery in the various colonies. The unique importance of the Brazilian free labor class is stressed, just as is the very unusual mobility experienced by the free colored in the French West Indies. The final chapter deals with the differing history of total emancipation and how ex-slaves adjusted to free conditions in the post-abolition periods of their respective societies. The patterns of post-emancipation integration are studied along with the questions of the relative success of the ex-slaves in obtaining control over land and escape from the old plantation regimes.

African Slavery in Latin America and the Caribbean

Background: Treatment of differentiate d thyroid cancer has been studied for many years, but the benefits of exten­ sive initial thyroid surgery and the addition of radioiodine therapy or external radiation therapy remain controversial. Objective: To determine the relations among extent of surgery, radioiodine therapy, and external radiation ther­ apy in the treatment of high-risk papillary and nonHurthle-cell follicular thyroid carcinoma. Design: Analysis of data from a multicenter study. Setting: 14 institutions in the United States and Canada participating in the National Thyroid Cancer Treatment Cooperative Study Registry. Patients: 385 patients with high-risk thyroid cancer (303 with papillary carcinoma and 82 with follicular carcinoma). Measurements: Death, disease progression, and diseasefree survival. Results: Total or near-total thyroidectomy was done in 85.3% of patients with papillary carcinoma and 71.3% of patients with follicular cancer. Overall surgical complica­ tion rate was 14.3%. Total or near-total thyroidectomy improved overall survival (risk ratio [RR], 0.37 [95% CI, 0.18 to 0.75]) but not cancer-specific mortality, progression, or disease-free survival in patients with papillary cancer. No effect of extent of surgery was seen in patients with follic­ ular thyroid cancer. Postoperative iodine-131 was given to 85.4% of patients with papillary cancer and 79.3% of patients with follicular cancer. In patients with papillary cancer, radioiodine therapy was associated with improve­ ment in cancer-specific mortality (RR, 0.30 [CI, 0.09 to 0.93 by multivariate analysis only]) and progression (RR, 0.30 [CI, 0.13 to 0.72]). When tall-cell variants were excluded, the effect on outcome was not significant. After radioio­ dine therapy, patients with follicular thyroid cancer had improvement in overall mortality (RR, 0.17 [CI, 0.06 to 0.47]), cancer-specific mortality (RR, 0.12 [CI, 0.04 to 0.42]), progression (RR, 0.21 [CI, 0.08 to 0.56]), and disease-free survival (RR, 0.29 [CI, 0.08 to 1.01]). External radiation therapy to the neck was given to 18.5% of patients and was not associated with improved survival, lack of progres­ sion, or disease-free survival. Conclusions: This study supports improvement in overall and cancer-specific mortality among patients with papil­ lary and follicular thyroid cancer after postoperative io­ dine-131 therapy. Radioiodine therapy was also associated with improvement in progression in patients with papil­ lary cancer and improvement in progression and diseasefree survival in patients with follicular carcinoma.

Herbert S. Klein

Papers

The Atlantic Slave Trade

African Slavery in Latin America and the Caribbean

African Slavery in Latin America and the Caribbean

Outcome after Treatment of High-Risk Papillary and Non-Hurthle-Cell Follicular Thyroid Carcinoma

The Middle Passage: Comparative Studies in the Atlantic Slave Trade