Marihuana Chemistry: Recent advances in cannabinoid chemistry open the area to more sophisticated biological research.

Certain trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-ones and the corresponding ring-opened acids derived therefrom which are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG CoA reductase and are thus useful hypolipidemic or hypocholesterolemic agents. Pharmaceutical compositions containing such compounds, and a method of inhibiting the biosynthesis of cholesterol employing such pharmaceutical compositions are also disclosed.

Trans-6-[2-(3- or 4-Carboxamido-substituted pyrrol-1-yl)-alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis

The present invention is directed to charged lipids, compositions comprising charged lipids, and the use of these compositions in drug delivery, targeted drug delivery, therapeutic imaging and diagnostic imaging, as well as their use as contrast agents.

Charged lipids and uses for the same

Compounds of this invention are non-peptide, reversible inhibitors of type 2 methionine aminopeptidase, useful in treating conditions mediated by angiogenesis, such as cancer, haemangioma, proliferative retinopathy, rheumatoid arthritis, atherosclerotic neovascularization, psoriasis, ocular neovascularization and obesity.

Compounds and methods

Publisher Summary This chapter discusses receptor-proteins for androgens and the mode of action of androgens on gene transcription in ventral prostate. The primary molecular processes by which hormones elicit their remarkable effects are still unclear. Historically, the study of the mechanism of action of hormones has followed very closely the advance in knowledge of the basic molecular processes operating in living organisms. It is quite natural that one of the most widely used approaches has been to study the effect of hormones on isolated enzymes. With few exceptions, the results have been rather disappointing. Generally, the effects were observable only under conditions unlikely to be physiological, or they could not be correlated with in vivo situations. In the search for the trigger mechanisms of hormones, one generally relies on the trial addition of hormones to an in vitro system believed to be the earliest event in a sequence of hormone effects in vivo. However, the in vivo time sequences for visible hormone effects may depend more on the relative time required to magnify each of the sequential events than on the true order in the initial chain of processes.

Receptor-proteims for androgens and the mode of action of androgens on gene transcription in ventral prostate.

Biological effects of racemic and resolved 13β-ethyl-4-gonen-3-ones

The identification of some human metabolites of norgestrel, a new progestational agent.

Biological Effects of Synthetic Gonanes

Totally synthetic steroid hormones. 13. The chemical resolution of some racemic estrane, 13-beta-ethylgonane, and 13-beta-n-propylgonane derivatives and the preparation of some estrane and 13-beta-ethylgonane derivatives of unnatural configuration.

Herchel Smith

Papers

Biological effects of racemic and resolved 13β-ethyl-4-gonen-3-ones

The identification of some human metabolites of norgestrel, a new progestational agent.

Biological Effects of Synthetic Gonanes

Totally synthetic steroid hormones. 13. The chemical resolution of some racemic estrane, 13-beta-ethylgonane, and 13-beta-n-propylgonane derivatives and the preparation of some estrane and 13-beta-ethylgonane derivatives of unnatural configuration.

Total synthesis of .DELTA.8-(.DELTA.1(6)-tetrahydrocannabinol, a biologically active constituent of hashish (marijuana)