The formation of delta 9-unsaturated fatty acids.

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The intraluminal phase of fat digestion in man: the lipid content of the micellar and oil phases of intestinal content obtained during fat digestion and absorption.

Separations of lipids by silver ion chromatography.

The progress made in the knowledge of the microsomal fatty acid desaturation reaction is described:

The oxidative desaturation of unsaturated fatty acids in animals

Publisher Summary This chapter discusses the biochemistry of drug oxidation and reduction by enzymes in hepatic endoplasmic reticulum. In studying the action of drugs in the body, it is important not only to determine the mechanisms through which drugs elicit their pharniacological effect, but, also to study the factors which control their concentration at active sites. The conccntration of some drugs are controlled mainly by their relative rates of absorption and excretion. Most drugs, however, are converted to other substances before they are excreted into air, bile, and urine, and thus their rates of metabolism may be a major factor in limiting their action. Indeed, the pharmacological effects of highly bound drugs, such as chlorpromazine, phenylbutazone, and thiopental, would last for virtually a lifetime if they were not converted to inactive metabolites which were readily excreted.

Biochemistry of Drug Oxidation and Reduction by Enzymes in Hepatic Endoplasmic Reticulum

We tried to prove the conversion of stearic acid into oleic acid by liver extracts. The method described by LE BRETON and co-workers results in enzyme preparations from rat liver which decolorize methylenblue very rapidly but do not dehydrogenate stearic to oleic acid.



After fractionation of liver cell particles in sucrose solution we were able to prove the existence of a dehydrogenase in the supernatant containing microsomes and cytoplasma, which converts 14C stearic acid into oleic acid. The mytochondrial fraction showed no activity.

Die enzymatische Dehydrierung der Stearinsäure zu Ölsäure

Distribution and half life of erucic acid after rape seed oil administration in rats

Life time of linoleic acid in the organism of rats

Studies on the behavior of linolenic acid in animals

A method is described by which saturated and unsaturated fatty acids with 12–22 C atoms can be separated by paper chromatography. By measuring the light absorption of the copper-ferrocyanide complexes developed from the fatty acids on the paper a satisfactory quantitative analysis of such fatty acid mixtures was possible.

Heribert Wagner

Papers

Die enzymatische Dehydrierung der Stearinsäure zu Ölsäure

Distribution and half life of erucic acid after rape seed oil administration in rats

Life time of linoleic acid in the organism of rats

Studies on the behavior of linolenic acid in animals

Zur papierchromatographischen Analyse von Fettsäuregemischen aus gesättigten und ungesättigten Fettsäuren mit 12 bis 22 C-Atomen