Showing papers by "Herman Chernoff published in 1991"
4 citations
01 Oct 1991
TL;DR: In this paper, a sample of sperm from a single donor is analyzed to see which alleles (distinct forms of the various genes) are present in the individual sperms.
Abstract: : Two technologies applicable to gene mapping are those of sperm typing and radiation hybrid mapping. Sperm typing makes use of the polymerase chain reaction, a biochemical technique which allows enormous amplification (production of multiple copies) of small, selected DNA fragments from a single chromosome. A sample of sperm from a single donor is analyzed to see which alleles (distinct forms of the various genes) are present in the individual sperms. The frequencies with which the various possibilities occur can be used to supply estimates of the ordering and of the recombination probabilities among the genes for which that donor is heterozygous (having different alleles of the same gene.)
4 citations
TL;DR: In this paper, two computer intensive methods are proposed for quick and dirty estimates of parameters of complex parametric models, which require the ability to simulate data from the model, and to do simple matrix calculations.
2 citations