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Hermi Sumatoh
Researcher at Agency for Science, Technology and Research
Publications - 17
Citations - 2598
Hermi Sumatoh is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Cytotoxic T cell & Immune system. The author has an hindex of 13, co-authored 17 publications receiving 1977 citations. Previous affiliations of Hermi Sumatoh include Singapore Immunology Network & University of Western Australia.
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Journal ArticleDOI
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species.
Martin Guilliams,Martin Guilliams,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Charlotte L. Scott,Naomi McGovern,Dorine Sichien,Svetoslav Chakarov,Sofie Van Gassen,Jinmiao Chen,Michael Poidinger,Sofie De Prijck,Simon Tavernier,Ivy Low,Sergio Erdal Irac,Citra Nurfarah Zaini Mattar,Hermi Sumatoh,Gillian Low,Tam John Kit Chung,Dedrick Kok Hong Chan,Ker-Kan Tan,Tony Lim Kiat Hon,Even Fossum,Bjarne Bogen,Mahesh Choolani,Jerry Kok Yen Chan,Anis Larbi,Hervé Luche,Sandrine Henri,Yvan Saeys,Evan W. Newell,Bart N. Lambrecht,Bart N. Lambrecht,Bernard Malissen,Florent Ginhoux +34 more
TL;DR: A universal toolbox for the automated identification of DCs through unsupervised analysis of conventional flow cytometry and mass cytometry data obtained from multiple mouse, macaque, and human tissues is provided and validated.
Journal ArticleDOI
Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow
Andreas Schlitzer,V. Sivakamasundari,Jinmiao Chen,Hermi Sumatoh,Jaring Schreuder,Josephine Lum,Benoit Malleret,Sanqian Zhang,Anis Larbi,Francesca Zolezzi,Laurent Rénia,Michael Poidinger,Shalin H. Naik,Evan W. Newell,Paul Robson,Florent Ginhoux +15 more
TL;DR: This work found that transcriptional signatures of the cDC1 and cDC2 lineages became evident at the single-cell level from the CDP stage, and identified Siglec-H and Ly6C as lineage markers that distinguished pre-DC subpopulations committed to the c DC1 lineage (SigleC-H−Ly6C− pre- DCs) or c DC2 lineage (CDC2 lineage).
Journal ArticleDOI
Mapping the human DC lineage through the integration of high-dimensional techniques
Peter See,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Jinmiao Chen,Patrick Günther,Naomi McGovern,Sergio Erdal Irac,Merry Gunawan,Marc Beyer,Marc Beyer,Kristian Händler,Kaibo Duan,Hermi Sumatoh,Nicolas Ruffin,Mabel Jouve,Ester Gea-Mallorquí,Raoul C.M. Hennekam,Tony Kiat Hon Lim,Chan Chung Yip,Ming Wen,Benoit Malleret,Benoit Malleret,Ivy Low,Nurhidaya Binte Shadan,Charlene Foong Shu Fen,Alicia Tay,Josephine Lum,Francesca Zolezzi,Anis Larbi,Michael Poidinger,Jerry Kok Yen Chan,Qingfeng Chen,Laurent Rénia,Muzlifah Haniffa,Philippe Benaroch,Andreas Schlitzer,Andreas Schlitzer,Joachim L. Schultze,Joachim L. Schultze,Evan W. Newell,Florent Ginhoux +40 more
TL;DR: Two unbiased high-dimensional technologies are employed to characterize the human DC lineage from bone marrow to blood and provide new markers that can be used to identify unambiguously pre-DC from pDC, including CD33, CX3CR1, CD2, CD5, and CD327.
Journal ArticleDOI
High-dimensional analysis of the murine myeloid cell system.
Burkhard Becher,Andreas Schlitzer,Jinmiao Chen,Florian Mair,Hermi Sumatoh,Karen Wei Weng Teng,Donovan Low,Christiane Ruedl,Paola Riccardi-Castagnoli,Michael Poidinger,Melanie Greter,Florent Ginhoux,Evan W. Newell +12 more
TL;DR: A 38-antibody panel for mass cytometry was developed and used dimensionality reduction with machine learning–aided cluster analysis to build a composite of murine (mouse) myeloid cells in the steady state across lymphoid and nonlymphoid tissues, and variations in the monocyte and innate lymphoid cell compartment that were unexpected were identified.
Journal ArticleDOI
Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2
Naomi McGovern,Amanda Shin,Amanda Shin,Gillian Low,Donovan Low,Kaibo Duan,Leong Jing Yao,Rasha Msallam,Ivy Low,Nurhidaya Binte Shadan,Hermi Sumatoh,Erin Soon,Josephine Lum,Esther Wing Hei Mok,Sandra Hubert,Peter See,Edwin Huang Kunxiang,Yie Hou Lee,Yie Hou Lee,Baptiste Janela,Mahesh Choolani,Citra Nurfarah Zaini Mattar,Yiping Fan,Yiping Fan,Tony Kiat Hon Lim,Dedrick Kok Hong Chan,Ker-Kan Tan,Ker-Kan Tan,John Kit Chung Tam,Christopher Schuster,Adelheid Elbe-Bürger,Xiao-Nong Wang,Venetia Bigley,Matthew Collin,Muzlifah Haniffa,Andreas Schlitzer,Andreas Schlitzer,Andreas Schlitzer,Michael Poidinger,Salvatore Albani,Anis Larbi,Evan W. Newell,Jerry Kok Yen Chan,Florent Ginhoux +43 more
TL;DR: The results reveal a previously unappreciated role of dendritic cells within the developing fetus and indicate that they mediate homeostatic immune-suppressive responses during gestation.