H
Herndon Douglas
Researcher at University of California, San Diego
Publications - 26
Citations - 2527
Herndon Douglas is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Antiserum & Bacteremia. The author has an hindex of 19, co-authored 26 publications receiving 2487 citations.
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Journal ArticleDOI
Selective Protection against Conidia by Mononuclear and against Mycelia by Polymorphonuclear Phagocytes in Resistance to Aspergillus: OBSERVATIONS ON THESE TWO LINES OF DEFENSE IN VIVO AND IN VITRO WITH HUMAN AND MOUSE PHAGOCYTES
TL;DR: Cortisone inhibited the conidiacidal activity of mouse macrophages in vivo and of human or mouse mononuclear phagocytes in vitro and reduced the mobilization of PMN so that the second line of defense was also impaired, indicating that cortisone can break down natural resistance on its own.
Journal ArticleDOI
Protection against gram-negative bacteremia and endotoxemia with human monoclonal IgM antibodies.
Nelson N.H. Teng,Henry S. Kaplan,Joan M. Hebert,Cynthia Moore,Herndon Douglas,Annette C. Wunderlich,Abraham I. Braude +6 more
TL;DR: Findings indicate that monoclonal IgM against LPS endotoxin can neutralize its toxicity in vivo and might be valuable for treatment of patients with Gram-negative bacteremia.
Journal Article
Treatment of E. Coli and Klebsiella Bacteremia in Agranulocytic Animals with Antiserum to a UDP-GAL Epimerase-Deficient Mutant
TL;DR: R rabbits immunized with a UDP-galactose-deficient mutant (J5) of Escherichia coli O111 that is unencumbered by O antigen since it cannot incorporate galactose into core LPS produced broad protection against different Gramnegative bacteria.
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Encystation and expression of cyst antigens by Giardia lamblia in vitro
Frances D. Gillin,David S. Reiner,Michael J. Gault,Herndon Douglas,Siddhartha Das,Annette C. Wunderlich,Judith F. Sauch +6 more
TL;DR: In these studies, encystation of Giardia lamblia in vitro was demonstrated by morphologic, immunologic, and biochemical criteria and will aid in understanding the differentiation of an important protozoan pathogen.
Journal ArticleDOI
In vitro susceptibility of fungi to killing by neutrophil granulocytes discriminates between primary pathogenicity and opportunism.
TL;DR: Four virulent dimorphic yeasts were ingested by neutrophils, and triggered a respiratory burst comparably to opportunists but were less susceptible to hydrogen peroxide, suggesting that differences in the susceptibility to microbicidal products of leukocytes may explain the difference in virulence.