H
Hideaki Kakeya
Researcher at Kyoto University
Publications - 269
Citations - 7074
Hideaki Kakeya is an academic researcher from Kyoto University. The author has contributed to research in topics: Total synthesis & Nonribosomal peptide. The author has an hindex of 41, co-authored 258 publications receiving 6129 citations. Previous affiliations of Hideaki Kakeya include Kyoto Pharmaceutical University & University of Shizuoka.
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Journal ArticleDOI
RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock
Jean-Michel Fustin,Masao Doi,Yoshiaki Yamaguchi,Hayashi Hida,Shinichi Nishimura,Minoru Yoshida,Takayuki Isagawa,Masaki Suimye Morioka,Hideaki Kakeya,Ichiro Manabe,Hitoshi Okamura +10 more
TL;DR: It is reported that inhibition of transmethylation reactions elongates the circadian period and methylation inhibition causes widespread changes in the transcription of the RNA processing machinery, associated with m(6)A-RNA methylation.
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Innovative preparation of curcumin for improved oral bioavailability.
Hiroki Sasaki,Yoichi Sunagawa,Yoichi Sunagawa,Kenji Takahashi,Atsushi Imaizumi,Hiroyuki Fukuda,Tadashi Hashimoto,Hiromichi Wada,Yasufumi Katanasaka,Hideaki Kakeya,Masatoshi Fujita,Koji Hasegawa,Tatsuya Morimoto +12 more
TL;DR: THERACURMIN exhibited an inhibitory action against alcohol intoxication after drinking in humans, as evidenced by the reduced acetaldehyde concentration of the blood, and shows a much higher bioavailability than currently available preparations.
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Spirotryprostatin B, a Novel Mammalian Cell Cycle Inhibitor Produced by Aspergillus fumigatus
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Novel mammalian cell cycle inhibitors, spirotryprostatins A and B, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M phase☆
TL;DR: Spirotryprostatins A and B had a novel structural skeleton with an unique spiro ring system and inhibited the cell cycle progression of tsFT210 cells at the G2/M phase with IC50 values of 197.5 μM and 14.0 μM, respectively.
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Novel Mammalian Cell Cycle Inhibitors, Tryprostatins A, B and Other Diketopiperazines Produced by Aspergillus fumigatus I. Taxonomy, Fermentation, Isolation and Biological Properties
TL;DR: The diketopiperazines showed an inhibitory activity on the cell cycle progression of mouse tsFT210 cells in the M phase with the MIC values of 16.4 microM and 12.2 microM, respectively.