H
Hideji Itokawa
Researcher at University of North Carolina at Chapel Hill
Publications - 23
Citations - 1479
Hideji Itokawa is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Prostate cancer & Androgen Receptor Antagonists. The author has an hindex of 17, co-authored 23 publications receiving 1383 citations.
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Journal ArticleDOI
Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents.
Hironori Ohtsu,Zhiyan Xiao,Junko Ishida,Masahiro Nagai,Hui Kang Wang,Hideji Itokawa,Ching-Yuan Su,Charles C. Y. Shih,Tzuying Chiang,Eugene Chang,Yi-Fen Lee,Meng Yin Tsai,Chawnshang Chang,Kuo Hsiung Lee +13 more
TL;DR: Curcumin analogues, compounds 4, 20, 22, 23, and 39 have been identified as a new class of antiandrogen agents, and they could be developed into clinical trial candidates to control androgen receptor-mediated prostate cancer growth.
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Recent advances in the investigation of curcuminoids
TL;DR: The literature between 1976 and mid-2008 on the anti-inflammatory, anti-oxidant,Anti-HIV, chemopreventive and anti-prostate cancer effects of curcuminoids are reviewed.
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Plant-derived natural product research aimed at new drug discovery.
TL;DR: Research on many different useful compounds isolated or developed from plants with emphasis placed on those recently discovered by the authors’ laboratories as antitumor and anti-HIV clinical trial candidates are summarized.
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Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents.
Junko Ishida,Hironori Ohtsu,Yoko Tachibana,Yuka Nakanishi,Kenneth F. Bastow,Masahiro Nagai,Hui Kang Wang,Hideji Itokawa,Kuo Hsiung Lee +8 more
TL;DR: Curcumin compound was the most potent analogue against several cell lines, including HOS and 1A9 (breast cancer), with ED50 values of 0.97 and <0.63 microg/mL, respectively.
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Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents.
Jin Tatsuzaki,Kenneth F. Bastow,Kyoko Nakagawa-Goto,Seiko Nakamura,Hideji Itokawa,Kuo Hsiung Lee +5 more
TL;DR: Twenty-eight compounds related to dehydrozingerone, isoeugenol, and 2-hydroxychalcone were synthesized and evaluated in vitro against human tumor cell replication and exhibited moderate or strong cytotoxic activity against KB, KB-VCR, and A549 cell lines.