H
Hidenori Otsuka
Researcher at Tokyo University of Science
Publications - 116
Citations - 4807
Hidenori Otsuka is an academic researcher from Tokyo University of Science. The author has contributed to research in topics: Ethylene glycol & PEG ratio. The author has an hindex of 26, co-authored 108 publications receiving 4506 citations. Previous affiliations of Hidenori Otsuka include Hokkaido University & National Institute for Materials Science.
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PEGylated Nanoparticles for Biological and Pharmaceutical Applications
TL;DR: The potential utility of multimolecular assembly derived from heterobifunctional PEGs and block copolymers were explored to systematically modify the properties of metal and semiconductor nanostructures by controlling their structure and their surface properties, making them extremely attractive for use in biological and biomedical applications.
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Quantitative and Reversible Lectin-Induced Association of Gold Nanoparticles Modified with α-Lactosyl-ω-mercapto-poly(ethylene glycol)
TL;DR: Lac-conjugated gold nanoparticles exhibited selective aggregation when exposed to Recinus communis agglutinin (RCA120), a bivalent lectin specifically recognizing the β-d-galactose residue, inducing significant changes in the absorption spectrum with concomitant visible color change from pinkish-red to purple.
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Anomalous binding profile of phenylboronic acid with N-acetylneuraminic acid (Neu5Ac) in aqueous solution with varying pH.
TL;DR: In this article, the anomalous binding profile of borate in aqueous solution with N-acetylneuraminic acid (Neu5Ac, sialic acid) was revealed.
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Self-assembly of poly(ethylene glycol)-based block copolymers for biomedical applications
TL;DR: Novel approaches for the construction of functionalized poly(ethylene glycol) (PEG) layers on surfaces were focused to attain the specific adsorption of a target protein through PEG-conjugated ligands with a minimal non-specific adsor adaptation of other proteins.
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Preparation of functionally PEGylated gold nanoparticles with narrow distribution through autoreduction of auric cation by α-Biotinyl-PEG-block-[poly(2-(N,N-dimethylamino)ethyl methacrylate)]
TL;DR: Biotinyl-PEG/PAMA-anchored gold nanoparticles underwent specific aggregation in the presence of streptavidin, revealing their promising utility as colloidal sensing systems applicable under biological condition.