H
Hideo Utsumi
Researcher at Kyushu University
Publications - 183
Citations - 10544
Hideo Utsumi is an academic researcher from Kyushu University. The author has contributed to research in topics: Nitroxyl & Oxidative stress. The author has an hindex of 49, co-authored 182 publications receiving 9931 citations. Previous affiliations of Hideo Utsumi include University of Shizuoka & Ochanomizu University.
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Journal ArticleDOI
High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.
Toyoshi Inoguchi,Ping Li,Fumio Umeda,Hai Yan Yu,Maiko Kakimoto,Minako Imamura,Tsuyoshi Aoki,Takashi Etoh,Toshihiko Hashimoto,Masaichi Naruse,Hiroaki Sano,Hideo Utsumi,Hajime Nawata +12 more
TL;DR: Both high glucose level and palmitate may stimulate ROS production through PKC-dependent activation of NAD(P)H oxidase in both vascular SMCs and ECs, which may be involved in the excessive acceleration of atherosclerosis in patients with diabetes and insulin resistance syndrome.
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Mitochondrial Electron Transport Complex I Is a Potential Source of Oxygen Free Radicals in the Failing Myocardium
Tomomi Ide,Hiroyuki Tsutsui,Shintaro Kinugawa,Hideo Utsumi,Dongchon Kang,Nobutaka Hattori,Koji Uchida,Ken ichi Arimura,Kensuke Egashira,Akira Takeshita +9 more
TL;DR: Direct evidence is provided for the involvement of ROS in the mitochondrial origin of HF myocytes, which might be responsible for both contractile dysfunction and structural damage to the myocardium.
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Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction.
Tomomi Ide,Hiroyuki Tsutsui,Shunji Hayashidani,Dongchon Kang,Nobuhiro Suematsu,Kei-ichiro Nakamura,Hideo Utsumi,Naotaka Hamasaki,Akira Takeshita +8 more
TL;DR: It is hypothesized that ROS may induce mitochondrial DNA (mtDNA) damage, which leads to defects of mtDNA-encoded gene expression and respiratory chain complex enzymes and thus may contribute to the progression of left ventricular remodeling and failure after myocardial infarction.
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Nox4 as the Major Catalytic Component of an Endothelial NAD(P)H Oxidase
Tetsuro Ago,Takanari Kitazono,Hiroaki Ooboshi,Teruaki Iyama,Youn Hee Han,Junichi Takada,Masanori Wakisaka,Setsuro Ibayashi,Hideo Utsumi,Mitsuo Iida +9 more
TL;DR: Findings suggest that Nox4 may function as the major catalytic component of an endothelial NAD(P)H oxidase, a homologue of gp91phox/Nox2, which was abundantly expressed in endothelial cells.
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Estrogenic Activities of 517 Chemicals by Yeast Two-Hybrid Assay
Tsutomu Nishihara,Jun-ichi Nishikawa,Tomohiko Kanayama,Fumi Dakeyama,Koichi Saito,Masayoshi Imagawa,Satoshi Takatori,Yoko Kitagawa,Shinjiro Hori,Hideo Utsumi +9 more
TL;DR: A simple and rapid screening method using the yeast two-hybrid system based on the ligand-dependent interaction of nuclear hormone receptors with coactivators to test the estrogenic activity of chemicals.