H
Hideyo Yasuda
Researcher at University of Tokyo
Publications - 54
Citations - 7632
Hideyo Yasuda is an academic researcher from University of Tokyo. The author has contributed to research in topics: Ubiquitin ligase & Ubiquitin. The author has an hindex of 35, co-authored 54 publications receiving 7372 citations.
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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
TL;DR: The data suggest that the MDM2 protein, which is induced by p53, functions as a ubiquitin ligase, E3, in human papillomavirus‐uninfected cells which do not have E6 protein.
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Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
Reiko Honda,Hideyo Yasuda +1 more
TL;DR: The ubiquitin ligase activity of Mdm2 for p53 is characterized and it is suggested that DNA damage‐induced phosphorylation stabilizes p53 by inhibiting its ubiquitination by MDM2.
Journal ArticleDOI
Involvement of PIAS1 in the Sumoylation of Tumor Suppressor p53
TL;DR: Data suggest that PIAS1 functions as a SUMO ligase, or possibly as a tightly bound regulator of it, toward p53, the key enzyme in the recognition of substrates to be sumoylated by the ubiquitin-like protein.
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Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
R Honda,Hideyo Yasuda +1 more
TL;DR: The data indicate that the RING finger domain in MDM2 is essential for its ubiquitin ligase activity toward p53 and itself, and also for the diminishing of the activity by the mutation.
Journal ArticleDOI
Evidence that reactive oxygen species do not mediate NF‐κB activation
Makio Hayakawa,Hiroshi Miyashita,Isao Sakamoto,Masatoshi Kitagawa,Hirofumi Tanaka,Hideyo Yasuda,Michael Karin,Kiyomi Kikugawa +7 more
TL;DR: Evidence is presented that endogenous ROS produced through Rac/NADPH oxidase do not mediate NF‐κB signaling, but instead lower the magnitude of its activation, and this hypothesis is mainly based on the findings that N‐acetyl‐L‐cysteine and pyrrolidine dithiocarbamate, compounds recognized as potential antioxidants, can inhibit NF-κB activation in a wide variety of cell types.