H
Hideyuki Okano
Researcher at Keio University
Publications - 1258
Citations - 75216
Hideyuki Okano is an academic researcher from Keio University. The author has contributed to research in topics: Stem cell & Neural stem cell. The author has an hindex of 128, co-authored 1169 publications receiving 67148 citations. Previous affiliations of Hideyuki Okano include Yokohama City University & Tokyo Institute of Technology.
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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara,Kenji Nakamura,Makoto Matsui,Makoto Matsui,Makoto Matsui,Akitsugu Yamamoto,Yohko Nakahara,Rika Suzuki-Migishima,Minesuke Yokoyama,Kenji Mishima,Ichiro Saito,Hideyuki Okano,Noboru Mizushima +12 more
TL;DR: The results suggest that the continuous clearance of diffuse cytosolic proteins through basal autophagy is important for preventing the accumulation of abnormal proteins, which can disrupt neural function and ultimately lead to neurodegeneration.
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Variation in the safety of induced pluripotent stem cell lines
Kyoko Miura,Yohei Okada,Takashi Aoi,Aki Okada,Kazutoshi Takahashi,Keisuke Okita,Masato Nakagawa,Michiyo Koyanagi,Koji Tanabe,Mari Ohnuki,Daisuke Ogawa,Eiji Ikeda,Hideyuki Okano,Shinya Yamanaka +13 more
TL;DR: This study evaluated the teratoma-forming propensity of secondary neurospheres generated from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways, which correlated with the persistence of undifferentiated cells.
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Asymmetric Inheritance of Radial Glial Fibers by Cortical Neurons
TL;DR: This work intensively monitored divisions of RGCs in DiI-labeled slices from the embryonic day 14 mouse cortex and revealed the fate of radial glial processes, which lead to ascent of the neuron by using the "recycled" radial fiber.
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Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.
Seiji Okada,Masaya Nakamura,Hiroyuki Katoh,Tamaki Miyao,Takuya Shimazaki,Ken Ishii,Junichi Yamane,Akihiko Yoshimura,Yukihide Iwamoto,Yoshiaki Toyama,Hideyuki Okano +10 more
TL;DR: It is suggested that Stat3 is a key regulator of reactive astrocytes in the healing process after SCI, providing a potential target for intervention in the treatment of CNS injury.