Hifza Rasheed

Bio: Hifza Rasheed is an academic researcher from University of Leeds. The author has contributed to research in topics: Population & Arsenic. The author has an hindex of 7, co-authored 13 publications receiving 184 citations.

Human health risk assessment for arsenic: A critical review

Abstract: Millions of people are exposed to arsenic resulting in a range of health implications. This paper provides an up-to-date review of the different sources of arsenic (water, soil, and food), indicators of human exposure (biomarker assessment of hair, nail, urine, and blood), epidemiological and toxicological studies on carcinogenic and noncarcinogenic health outcomes, and risk assessment approaches. The review demonstrates a need for more work evaluating the risks of different arsenic species such as, arsenate, arsenite monomethylarsonic acid, monomethylarsonous acid, dimethylarsinic acid, and dimethylarsinous acid as well as a need to better integrate the different exposure sources in risk assessments.

Estimating the health burden of aflatoxin attributable stunting among children in low income countries of Africa.

Abstract: Numerous population-based studies have documented high prevalence of aflatoxin associated childhood stunting in low income countries. We provide an estimate of the disease burden of aflatoxin related stunting using data from the four African countries. For this empirical analysis, we obtained blood aflatoxin albumin adduct biomarker based exposure data as measured using ELISA technique and anthropometric measurement data from surveys done over a 12-year period from 2001 to 2012 in four low income countries in Africa. We used these data to calculate population attributable risk (PAR), life time disease burden for children under five by comparing two groups of stunted children using both prevalence and incidence-based approaches. We combined prevalence estimates with a disability weight, measuring childhood stunting and co-occurrence of stunting-underweight to produce years lived with disability. Using a previously reported mortality, years of life lost were estimated. We used probabilistic analysis to model these associations to estimate the disability-adjusted life-years (DALYs), and compared these with those given by the Institute for Health Metrics and Evaluation’s Global Burden of Disease (GBD) 2016 study. The PAR increased from 3 to 36% for aflatoxin-related stunting and 14–50% for co-occurrence of stunting and underweight. Using prevalence-based approach, children with aflatoxin related stunting resulted in 48,965.20 (95% uncertainty interval (UI): 45,868.75–52,207.53) DALYs per 100,000 individuals. Children with co-occurrence of stunting and underweight due to exposure to aflatoxin resulted in 40,703.41 (95% UI: 38,041.57–43,517.89) DALYs per 100,000 individuals. Uncertainty analysis revealed that reducing aflatoxin exposure in high exposure areas upto non-detectable levels could save the stunting DALYs up to 50%. The burden of childhood all causes stunting is greater in countries with higher aflatoxin exposure such as Benin. In high exposure areas, these results might help guide research protocols and prioritisation efforts and focus aflatoxin exposure reduction. HEFCE Global Challenge Research Fund Aflatoxin project.

Ministry of Statistics and Programme Implementation

Abstract: Meeting: International Seminar on Information and Communication Technology Statistics, Seoul, Republic of Korea, 19-21 July 2010

Arsenic uptake, toxicity, detoxification, and speciation in plants : physiological, biochemical, and molecular aspects

Abstract: Environmental contamination with arsenic (As) is a global environmental, agricultural and health issue due to the highly toxic and carcinogenic nature of As. Exposure of plants to As, even at very low concentration, can cause many morphological, physiological, and biochemical changes. The recent research on As in the soil-plant system indicates that As toxicity to plants varies with its speciation in plants (e.g., arsenite, As(III); arsenate, As(V)), with the type of plant species, and with other soil factors controlling As accumulation in plants. Various plant species have different mechanisms of As(III) or As(V) uptake, toxicity, and detoxification. This review briefly describes the sources and global extent of As contamination and As speciation in soil. We discuss different mechanisms responsible for As(III) and As(V) uptake, toxicity, and detoxification in plants, at physiological, biochemical, and molecular levels. This review highlights the importance of the As-induced generation of reactive oxygen species (ROS), as well as their damaging impacts on plants at biochemical, genetic, and molecular levels. The role of different enzymatic (superoxide dismutase, catalase, glutathione reductase, and ascorbate peroxidase) and non-enzymatic (salicylic acid, proline, phytochelatins, glutathione, nitric oxide, and phosphorous) substances under As(III/V) stress have been delineated via conceptual models showing As translocation and toxicity pathways in plant species. Significantly, this review addresses the current, albeit partially understood, emerging aspects on (i) As-induced physiological, biochemical, and genotoxic mechanisms and responses in plants and (ii) the roles of different molecules in modulation of As-induced toxicities in plants. We also provide insight on some important research gaps that need to be filled to advance our scientific understanding in this area of research on As in soil-plant systems.

Arsenic contamination of groundwater: A global synopsis with focus on the Indian Peninsula

Abstract: More than 2.5 billion people on the globe rely on groundwater for drinking and providing high-quality drinking water has become one of the major challenges of human society. Although groundwater is considered as safe, high concentrations of heavy metals like arsenic (As) can pose potential human health concerns and hazards. In this paper, we present an overview of the current scenario of arsenic contamination of groundwater in various countries across the globe with an emphasis on the Indian Peninsula. With several newly affected regions reported during the last decade, a significant increase has been observed in the global scenario of arsenic contamination. It is estimated that nearly 108 countries are affected by arsenic contamination in groundwater (with concentration beyond maximum permissible limit of 10 ppb recommended by the World Health Organization. The highest among these are from Asia (32) and Europe (31), followed by regions like Africa (20), North America (11), South America (9) and Australia (4). More than 230 million people worldwide, which include 180 million from Asia, are at risk of arsenic poisoning. Southeast Asian countries, Bangladesh, India, Pakistan, China, Nepal, Vietnam, Burma, Thailand and Cambodia, are the most affected. In India, 20 states and 4 Union Territories have so far been affected by arsenic contamination in groundwater. An attempt to evaluate the correlation between arsenic poisoning and aquifer type shows that the groundwater extracted from unconsolidated sedimentary aquifers, particularly those which are located within the younger orogenic belts of the world, are the worst affected. More than 90% of arsenic pollution is inferred to be geogenic. We infer that alluvial sediments are the major source for arsenic contamination in groundwater and we postulate a strong relation with plate tectonic processes, mountain building, erosion and sedimentation. Prolonged consumption of arsenic-contaminated groundwater results in severe health issues like skin, lung, kidney and bladder cancer; coronary heart disease; bronchiectasis; hyperkeratosis and arsenicosis. Since the major source of arsenic in groundwater is of geogenic origin, the extend of pollution is complexly linked with aquifer geometry and aquifer properties of a region. Therefore, remedial measures are to be designed based on the source mineral, climatological and hydrogeological scenario of the affected region. The corrective measures available include removing arsenic from groundwater using filters, exploring deeper or alternative aquifers, treatment of the aquifer itself, dilution method by artificial recharge to groundwater, conjunctive use, and installation of nano-filter, among other procedures. The vast majority of people affected by arsenic contamination in the Asian countries are the poor who live in rural areas and are not aware of the arsenic poisoning and treatment protocols. Therefore, creating awareness and providing proper medical care to these people remain as a great challenge. Very few policy actions have been taken at international level over the past decade to reduce arsenic contamination in drinking water, with the goal of preventing toxic impacts on human health. We recommend that that United Nations Environment Programme (UNEP) and WHO should take stock of the global arsenic poisoning situation and launch a global drive to create awareness among people/medical professionals/health workers/administrators on this global concern.