抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

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Principles Of Fluorescence Spectroscopy

Lanthanide-based luminescent hybrid materials.

This critical review will present the role of nanoparticles (NPs) in the directions that are vital to the new field of nanomedicine, including imaging and drug delivery. We reflect on the physical properties that make NPs advantageous for in vivo efficacy, and review recent advances in major NP based biomedical applications. Critical questions of transport, uptake, and clearance will be discussed and illustrated through the success and opportunities of NP imaging and therapy on a photodynamic therapy (PDT) based NP system that has been developed in our lab over the past decade (540 references).

The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy

A great deal of research has been carried out on lanthanide organic complex-based organic-inorganic hybrid materials in the last decade. This critical review begins with a formulation of the fundamentals of lanthanide organic complex luminescence, and presents various current designed ideas, synthetic routes, luminescence behaviors and potentials of the latest advanced (a) sol-gel materials, (b) mesoporous materials, (c) titania materials, (d) ionic liquids and ionogels, (e) polymers, and (f) bifunctional magnetic-optical composites based on lanthanide organic complexes. Finally, challenges and opportunities for further improvement of organic-inorganic hybrid luminescent materials based on lanthanide organic complexes will be discussed.

Hybrid materials based on lanthanide organic complexes: a review

A novel sulfobetaine copolymer is developed via polycondensation approach. The comonomers, melamine, condenses with a diketone, 5,5-dimethyl-1,3-cyclohexane (dimedone) to produce polyimine chain based on Schiff base chemistry. Dimedone-[N,N’ melaminium] propane sulfonate copolymer crystals were obtained on treatment of the polyimine with sulfopropylating agent, 1,3-propane sultone with a crosslinker, di(ethylene glycol diacrylate) (DEGDA). This crosslinked sulfobetaine polymer yielded fine needle like single crystals and shows strong blue fluorescence and a week green phosphorescence. Multi-exponential fluorescence decay function indicates the presence of different conformers both in solution and crystalline phase. This easy straightforward protocol for synthesis of crystalline, soluble, and luminescent polymer could prove to be a landmark in development of next generation smart functional materials.

Synthesis, Characterization and Photoluminescence Study of Novel Sulfobetaine Polyelectrolytes

/pdf/molecular-and-therapeutic-insights-of-alpha-lipoic-acid-as-a-2463gbtl.pdf

Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention

We report a Density Functional Theoretical (DFT) study of dissociation of Hydrogen Fluoride (HF) in HF(H 2O) 7 cluster, using B3LYP functional and empirical exchange correlation functional M06-2X along with 6-31 + G(d,p) basis set. Dissociation constant, K RP, of HF dissociation and pK a values of HF in cluster at various temperatures have been reported. It has been found that both K RP and pK a are highly dependent on temperature. The variation of pK a with temperature suggests that HF is strong acid at lower temperatures. Our study also reveals that HF is a stronger acid in water cluster than in bulk water. Further, the results obtained by DFT calculations have been compared with the earlier reported results obtained from Monte Carlo (MC) simulation. It is found that DFT results are qualitatively consistent with the results of MC simulation but quantitatively different.

/pdf/a-dft-study-of-temperature-dependent-dissociation-mechanism-590y4b62fw.pdf

A DFT study of temperature dependent dissociation mechanism of HF in HF(H2O)7 cluster

The energy transfer from Sm3+ and Eu3+ due to dipole–dipole interaction, variation in emission intensity of Sm3+ and Eu3+ peaks with varying concentration of Eu3+ and thermal stability of 2Sm3+, 2.5Eu3+ and 2Sm3+/2.5Eu3+ co-doped CaTiO3 phosphors.

Structure, photoluminescence properties, and energy transfer phenomenon in Sm3+/Eu3+ co-doped CaTiO3 phosphors

Excitation energy transfer/migration between fluorescent electron transport molecule tris(8-hydroxyquinoline) aluminum (donor) and fluorescent hole transport polymer poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] (acceptor) were studied in chloroform solution at room temperature using steady-state and time-domain fluorescence measurements. The blend of this pair is widely used in the fabrication of organic light-emitting diode. The considerable overlap integral between the emission spectrum of donor and absorption spectrum of acceptor indicates high donor–acceptor interaction, and the effective enhancement of the acceptor fluorescence along with a decrease in fluorescence intensity of donor by exciting the donor states characterized the excitation energy transfer between them. Relatively faster decay of donor in the presence of a higher concentration of acceptor followed the Forster kind of long-range fluorescence resonance energy transfer, which is illustrated by the agreement in the values of the energy transfer parameters observed from the fluorescence decay analysis and the values calculated from the spectral overlap. However, at lower acceptor concentrations, the excitation energy migration and diffusion/intrachain interaction influence the kinetics, resulting in a significant difference in the observed and calculated value of the energy transfer parameters. The influence of intrachain and interchain interactions during nonradiative excitation energy transfer is confirmed by the donor and acceptor decay dynamics on increasing acceptor concentration in donor–acceptor solution. No evidence of excimer formation is noticed in the donor–acceptor solution.

Excitation Energy Transfer/Migration between Tris(8-hydroxyquinoline) Aluminum and Poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] in Chloroform

Hirdyesh Mishra

Papers

Synthesis, Characterization and Photoluminescence Study of Novel Sulfobetaine Polyelectrolytes

Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention

A DFT study of temperature dependent dissociation mechanism of HF in HF(H2O)7 cluster

Structure, photoluminescence properties, and energy transfer phenomenon in Sm3+/Eu3+ co-doped CaTiO3 phosphors

Excitation Energy Transfer/Migration between Tris(8-hydroxyquinoline) Aluminum and Poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] in Chloroform