Hirdyesh Mishra

Bio: Hirdyesh Mishra is an academic researcher from Banaras Hindu University. The author has contributed to research in topics: Molecular orbital & Density functional theory. The author has an hindex of 20, co-authored 65 publications receiving 1086 citations. Previous affiliations of Hirdyesh Mishra include University of Maryland, Baltimore County & Kumaun University.

Excitation energy transfer between acriflavine and rhodamine 6G as a pH sensor

Abstract: Excitation energy transfer between acriflavine (donor) to rhodamine 6G (acceptor) molecules in water with varying pH has been studied by using steady state measurements. From absorption and fluorescence spectra of donor and acceptor, overlap integrals for donor fluorescence and donor absorption ( Ω DD ) as well as donor fluorescence and acceptor absorption ( Ω DA ) have been calculated. The corresponding critical transfer distances for dipole–dipole Forster mechanism of excitation energy transfer between donor–donor ( R 0D ) and donor–acceptor ( R 0A ), reduced concentration and efficiency of energy transfer have also been calculated. It has been found that the Ω DA change with pH whereas Ω DD remain unchanged, resulting in change in energy transfer from donor to acceptor with pH, but no change in energy migration. The efficiency of excitation energy transfer is maximum for a highly basic solution and it decreases with a decrease in pH. The energy transfer efficiency, reduced concentration, and overlap integrals show a linear dependence on pH. It has been proposed that the system may be used as a wide range (1.4 to 12) pH sensor with an accuracy of 0.01.

An efficient Hg2+ ensemble based on a triazole bridged anthracene and quinoline system for selective detection of cyanide through fluorescence turn-off–on response in solution and live cell

Abstract: A simple triazole bridged molecular probe containing anthracene and quinoline moieties has been designed and synthesized as a fluorescent molecular probe ( 7 ). The photophysical behavior of the probe 7 has been examined and tested for the recognition of ions in partial aqueous medium and HeLa cell. The probe 7 has shown strong affinity for Hg 2+ and has been utilized to develop a stable ensemble, 7·Hg 2 + . The ensemble, 7·Hg 2+ upon interaction with different class of anions showed high affinity for cyanide with ∼16 fold fluorescence enhancement and high limit of detection, 1.25 μM. The live cell imaging studies showed that ensemble 7·Hg 2+ is capable to detect CN − intracellularly. The analytical applicability of the probe for Hg 2+ and CN − has been tested on the test paper strips. Additionally, the naked eye sensitive “ On–Off–On ” switching behavior of 7 has been utilized to mimic the function of a sequential logic circuit at molecular level. The 1 H NMR titration, ESI-MS spectroscopy and DFT calculation confirms the binding behavior between 7 and Hg 2+ .

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

Principles Of Fluorescence Spectroscopy

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The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy

Abstract: This critical review will present the role of nanoparticles (NPs) in the directions that are vital to the new field of nanomedicine, including imaging and drug delivery. We reflect on the physical properties that make NPs advantageous for in vivo efficacy, and review recent advances in major NP based biomedical applications. Critical questions of transport, uptake, and clearance will be discussed and illustrated through the success and opportunities of NP imaging and therapy on a photodynamic therapy (PDT) based NP system that has been developed in our lab over the past decade (540 references).

Hybrid materials based on lanthanide organic complexes: a review

Abstract: A great deal of research has been carried out on lanthanide organic complex-based organic-inorganic hybrid materials in the last decade. This critical review begins with a formulation of the fundamentals of lanthanide organic complex luminescence, and presents various current designed ideas, synthetic routes, luminescence behaviors and potentials of the latest advanced (a) sol-gel materials, (b) mesoporous materials, (c) titania materials, (d) ionic liquids and ionogels, (e) polymers, and (f) bifunctional magnetic-optical composites based on lanthanide organic complexes. Finally, challenges and opportunities for further improvement of organic-inorganic hybrid luminescent materials based on lanthanide organic complexes will be discussed.