抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

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Principles Of Fluorescence Spectroscopy

Lanthanide-based luminescent hybrid materials.

This critical review will present the role of nanoparticles (NPs) in the directions that are vital to the new field of nanomedicine, including imaging and drug delivery. We reflect on the physical properties that make NPs advantageous for in vivo efficacy, and review recent advances in major NP based biomedical applications. Critical questions of transport, uptake, and clearance will be discussed and illustrated through the success and opportunities of NP imaging and therapy on a photodynamic therapy (PDT) based NP system that has been developed in our lab over the past decade (540 references).

The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy

A great deal of research has been carried out on lanthanide organic complex-based organic-inorganic hybrid materials in the last decade. This critical review begins with a formulation of the fundamentals of lanthanide organic complex luminescence, and presents various current designed ideas, synthetic routes, luminescence behaviors and potentials of the latest advanced (a) sol-gel materials, (b) mesoporous materials, (c) titania materials, (d) ionic liquids and ionogels, (e) polymers, and (f) bifunctional magnetic-optical composites based on lanthanide organic complexes. Finally, challenges and opportunities for further improvement of organic-inorganic hybrid luminescent materials based on lanthanide organic complexes will be discussed.

Hybrid materials based on lanthanide organic complexes: a review

Excitation energy transfer between the dye pair acriflavine (donor) to rhodamine-6G (acceptor) in various polymers [polyvinyl alcohol (PVA), cellulose acetate, and polymethyl methacrylate (PMMA)] was studied using steady-state and time-resolved fluorescence spectroscopy at room temperature. In all these polymers, at higher acceptor concentrations, direct energy transfer from acriflavine to rhodamine-6G followed the Forster theory, which is indicated by the agreement in the values of the observed critical transfer distance with that calculated from spectral overlap. On the other hand, at low acceptor concentrations, the excitation energy migration influences the kinetics, resulting in a significantly higher value of the observed critical transfer distance, which is explained on the basis of Loring et al. (Loring, R. F.; Anderson, H. C.; Fayer, M. D. J. Chem. Phys. 1984, 80, 5731−5744) and Huber (Huber, D. L. Phys. Rev. B:  Condens. Matter Mater. Phys. 1979, 20 2307−2314) theories. It was observed that the ...

Effect of polymer microenvironment on excitation energy migration and transfer.

Imidazole-coumarin containing D – A type fluorescent probe: Synthesis photophysical properties and sensing behavior for F− and CN− anion

Role of diffusion in excitation energy transfer: a time-resolved study

Photoinduced excited state dynamical processes in quinine sulphate dication (QSD) have been studied over a wide range of solute concentrations using steady state and nanosecond time-resolved fluorescence spectroscopic techniques The edge excitation red shift (EERS) of emission maximum, emission wavelength dependence of fluorescence lifetimes and the time dependence of emission maximum are known to occur due to the solvent relaxation process With increase in solute concentration, the emission spectrum shifts towards the lower frequencies accompanied with decrease in fluorescence intensity, however, absorption spectrum remains unchanged A decrease in EERS, fluorescence lifetimes, time dependent fluorescence Stokes shift (TDFSS), fluorescence polarization and the solvent relaxation time ( τ r ) is observed with the increase in solute concentration The process of energy migration among the QSD ions along with solvent relaxation has been found responsible for the above experimental findings

Edge excitation red shift and energy migration in quinine bisulphate dication

Photophysical and photochemical properties of 3-hydroxy-2-naphthoic acid [3,2-HNA] and 1-hydroxy-2naphthoic acid [1,2-HNA] in different aprotic, protic, and ion exchange (Nafion) polymers have been...

Hirdyesh Mishra

Papers

Effect of polymer microenvironment on excitation energy migration and transfer.

Imidazole-coumarin containing D – A type fluorescent probe: Synthesis photophysical properties and sensing behavior for F− and CN− anion

Role of diffusion in excitation energy transfer: a time-resolved study

Edge excitation red shift and energy migration in quinine bisulphate dication

Photo-induced relaxation and proton transfer in some hydroxy naphthoic acids in polymers.