抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

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Principles Of Fluorescence Spectroscopy

Lanthanide-based luminescent hybrid materials.

This critical review will present the role of nanoparticles (NPs) in the directions that are vital to the new field of nanomedicine, including imaging and drug delivery. We reflect on the physical properties that make NPs advantageous for in vivo efficacy, and review recent advances in major NP based biomedical applications. Critical questions of transport, uptake, and clearance will be discussed and illustrated through the success and opportunities of NP imaging and therapy on a photodynamic therapy (PDT) based NP system that has been developed in our lab over the past decade (540 references).

The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy

A great deal of research has been carried out on lanthanide organic complex-based organic-inorganic hybrid materials in the last decade. This critical review begins with a formulation of the fundamentals of lanthanide organic complex luminescence, and presents various current designed ideas, synthetic routes, luminescence behaviors and potentials of the latest advanced (a) sol-gel materials, (b) mesoporous materials, (c) titania materials, (d) ionic liquids and ionogels, (e) polymers, and (f) bifunctional magnetic-optical composites based on lanthanide organic complexes. Finally, challenges and opportunities for further improvement of organic-inorganic hybrid luminescent materials based on lanthanide organic complexes will be discussed.

Hybrid materials based on lanthanide organic complexes: a review

Combined experimental and theoretical studies on the diorganotin(IV) complexes of sparfloxacin: Synthesis, spectroscopic and DFT studies, and biological activity

Abstract The quantum-chemical calculations based on density functional theory (DFT) have been performed on the diphenyltin(IV) derivative of glycyl-phenylalanine (H2L) at the B3LYP/6-31G(d,p)/LANL2DZ(Sn) level of theory without any symmetry constraint. The harmonic vibrational frequencies were computed at the same level of theory to find the true potential energy surface minima. The various geometrical and thermochemical parameters for the studied complex are obtained in the gas phase. The atomic charges at all the atoms were calculated using the Mulliken population analysis, the Hirshfeld population analysis, and the natural population analysis. The charge distribution within the studied complex is explained on the basis of molecular electrostatic potential maps, frontier molecular orbital analysis, and conceptual DFT-based reactivity (global and local) descriptors, using the finite difference approximation method. The nature of O-Sn, N-Sn, N→Sn, and C-Sn bonds is discussed in terms of the conceptual DFT-based reactivity descriptors. The structural analysis of the studied complex has been conducted in terms of the selected bond lengths and bond angles. The structural and the atomic charge analyses suggest a distorted trigonal bipyramidal arrangement consisting of negatively charged centers around the positively charged central Sn atom.

A density functional theory insight into the structure and reactivity of diphenyltin(IV) derivative of glycylphenylalanine

Effect of Diffusion on Photo-Induced Excited-State Energy Transfer between Fluorescent Semiconducting Molecules: Tris-(8-hydroxyquinoline) Aluminum and 6,13-Bis (Triisopropylsilylethynyl) Pentacene

In the present work, we have used hydrothermally synthesized in situ functionalized MoS2-QDs for a sensitive (limit of detection ~ 2.06 µM) and selective detection of Fe3+ ions. A detailed study of fluorescence quenching behavior for MoS2-QDs in the presence of Fe3+ ions has been performed using the Stern–Volmer plot, modified Stern–Volmer plot, and time-resolved photoluminescence measurements. Absorption based titration spectra and time-resolved photoluminescence measurements confirmed the fluorescence quenching is static with three decay times originated from the three different fluorescing sites. Interestingly, it is found that emission spectra consist of three bands at positions ~ 450 nm (P1, ~ 2.76 eV), ~ 475 nm (P2, ~ 2.61 eV), and ~ 503 nm (P3, ~ 2.46 eV). These peaks show a systematic quenching with the increasing concentration of Fe3+ ions. Quenching constants corresponding to these emission bands are found of the order of ~ 103 M−1. Large values of bimolecular quenching constants (~ 1011 M−1 s−1) suggest a strong binding interaction between MoS2-QDs and Fe3+ ions. Furthermore, to understand the fluorescence quenching of MoS2-QDs in the presence of Fe3+ ions, a ground-state complex formation-based mechanism has been proposed and elucidated in detail.

Hirdyesh Mishra

Papers

Combined experimental and theoretical studies on the diorganotin(IV) complexes of sparfloxacin: Synthesis, spectroscopic and DFT studies, and biological activity

A density functional theory insight into the structure and reactivity of diphenyltin(IV) derivative of glycylphenylalanine

Effect of Diffusion on Photo-Induced Excited-State Energy Transfer between Fluorescent Semiconducting Molecules: Tris-(8-hydroxyquinoline) Aluminum and 6,13-Bis (Triisopropylsilylethynyl) Pentacene

Fluorescence quenching of molybdenum disulfide quantum dots for metal ion sensing

Polymer microenvironmental effects on the photophysics of cinchonine dication