H
Hiroaki Takayama
Researcher at Teikyo University
Publications - 157
Citations - 3175
Hiroaki Takayama is an academic researcher from Teikyo University. The author has contributed to research in topics: Calcitriol receptor & Metabolite. The author has an hindex of 27, co-authored 157 publications receiving 3075 citations. Previous affiliations of Hiroaki Takayama include University of the Ryukyus & University of Electro-Communications.
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Evidence That 2-Arachidonoylglycerol but Not N-Palmitoylethanolamine or Anandamide Is the Physiological Ligand for the Cannabinoid CB2 Receptor COMPARISON OF THE AGONISTIC ACTIVITIES OF VARIOUS CANNABINOID RECEPTOR LIGANDS IN HL-60 CELLS
Takayuki Sugiura,Sachiko Kondo,Seishi Kishimoto,Tomoyuki Miyashita,Shinji Nakane,Tomoko Kodaka,Yoshitomo Suhara,Hiroaki Takayama,Keizo Waku +8 more
TL;DR: 2-arachidonoylglycerol is the most potent compound among a number of naturally occurring cannabimimetic molecules, and anandamide and N-palmitoylethanolamine, other putative endogenous ligands, were found to be a weak partial agonist and an inactive ligand, respectively.
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Evidence That the Cannabinoid CB1 Receptor Is a 2-Arachidonoylglycerol Receptor STRUCTURE-ACTIVITY RELATIONSHIP OF 2-ARACHIDONOYLGLYCEROL, ETHER-LINKED ANALOGUES, AND RELATED COMPOUNDS
Takayuki Sugiura,Tomoko Kodaka,Shinji Nakane,Tomoyuki Miyashita,Sachiko Kondo,Yoshitomo Suhara,Hiroaki Takayama,Keizo Waku,Chiyo Seki,Naomichi Baba,Yoshio Ishima +10 more
TL;DR: The results strongly suggested that the cannabinoid CB1 receptor is originally a 2-arachidonoylglycerol receptor, and 2-Arachidonoyslglycersol is the intrinsic physiological ligand for the cannabinoidCB1 receptor.
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Efficient Synthesis of 2-Modified 1α,25-Dihydroxy-19-norvitamin D3 with Julia Olefination: High Potency in Induction of Differentiation on HL-60 Cells
Keiichiro Ono,Akihiro Yoshida,Nozomi Saito,Toshie Fujishima,Shinobu Honzawa,Yoshitomo Suhara,Yoshitomo Suhara,Seishi Kishimoto,Takayuki Sugiura,Keizo Waku,Hiroaki Takayama,Atsushi Kittaka +11 more
TL;DR: The synthesized 2alpha-(3-hydroxypropyl)-1alpha,25-dihydroxy-19-norvitamin D(3) (8a) showed almost the same potency in binding to the bovine thymus vitamin D receptor (VDR) as the natural hormone 1, while its beta-isomer 8b had only a 3% affinity.
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Ether-linked analogue of 2-arachidonoylglycerol (noladin ether) was not detected in the brains of various mammalian species
Saori Oka,Akiko Tsuchie,Akira Tokumura,Mayumi Muramatsu,Yoshitomo Suhara,Hiroaki Takayama,Keizo Waku,Takayuki Sugiura +7 more
TL;DR: It is found that 2‐AG ether is not present, at least in an appreciable amount, in the rat brain by gas chromatography‐mass spectrometry analysis and fluorometric high performance liquid chromatography analysis.
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Probing a water channel near the A-ring of receptor-bound 1α,25-dihydroxyvitamin D3 with selected 2α-substituted analogues
Shinji Hourai,Toshie Fujishima,Atsushi Kittaka,Yoshitomo Suhara,Hiroaki Takayama,Natacha Rochel,Dino Moras +6 more
TL;DR: In this paper, the crystal structures of the human VDR binding domain bound to selected C-2α substituted analogues, namely, methyl, propyl, propoxy, hydroxypropyl, and Hydroxypropoxy, were reported.