https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

2.4. Tandem sp-sp Coupling/Cyclization 3418 3. Cycloaddition Reactions 3418 3.1. [3+2] Cycloaddition 3418 3.1.1. Triazole/Isoxazole-Forming Reactions 3418 3.1.2. Reactions of Azomethine Ylides 3419 3.1.3. Cycloaddition of Nitrones 3422 3.1.4. Other [3+2] Reaction 3422 3.2. [4+2] Heterocycloaddition 3422 3.3. [2+2] Cycloaddition 3424 4. Cycloisomerization of Enynes/Diynes 3425 5. Intramolecular Friedel-Crafts-Type Reactions 3428 6. Reactions of R-Diazocarbonyl Compounds 3429 7. Aziridination of Olefins 3431 8. N/O-Vinylation/Arylation 3431 9. Radical Cyclization of Haloalkenes and Haloalkynes 3433

Coinage Metal-Assisted Synthesis of Heterocycles

Metal-Mediated Synthesis of Medium-Sized Rings

Hot compressed water (HCW, here water above 200 °C) possesses very interesting properties This series of articles gives an overview of the state of the art as regards the understanding of reactions in HCW In the first part the macroscopic and microscopic properties of HCW will be described, followed by a summary of synthesis reactions published The impact of the unique properties shall be discussed in part II, with the thermal degradation of tert-butylbenzene and the oxidation of methanol being used as examples The studies reported will show that the microscopic properties are of more importance to understanding reactions in HCW than assumed in the past

Hot compressed water as reaction medium and reactant properties and synthesis reactions

In this tutorial review the economies of synthesis are analysed from both detailed and macroscopic perspectives, using case-studies from complex molecule synthesis. Atom, step, and redox economy are more than philosophical constructs, but rather guidelines, which enable the synthetic chemist to design and execute an efficient synthesis. Students entering the field of synthesis might find this tutorial helpful for understanding the subtle differences between these economic principles and also see real-world situations where such principles are put into practice.

The economies of synthesis

The recommendation is developed that all synthetic chemists should always consider pressure as one of the routine variables available to them, along with temperature, solvent, reaction time, catalysts, and so forth. Ideally, equipment should be available both in the 1–5 and 10–20 kbar range, the former for the habitual testing of all reaction steps under increased pressure, and the latter for the more unusual instances in which gigapascal pressures appear to force otherwise reluctant reactions. The hope is that synthetic chemists will learn to optimize yields and conversions with respect to pressure as well as the other variables, and to report the pressure used just as routinely as they report reaction times and temperatures now.

Organic synthesis at high pressure

An efficient strategy for the iterative synthesis of a trans-fused polytetrahydropyran ring system via SmI2-induced reductive intramolecular cyclization

Hiroko Matsukura

Papers

Organic synthesis at high pressure

An efficient strategy for the iterative synthesis of a trans-fused polytetrahydropyran ring system via SmI2-induced reductive intramolecular cyclization

Efficient strategy for the iterative synthesis of trans-fused polycyclic ether via SmI2-induced reductive intramolecular cyclization

Total synthesis of hemibrevetoxin B

Stereoselective synthesis of six- and seven-membered ether rings based on the ring expansion