H
Hiroko Oshima
Researcher at Kanazawa University
Publications - 89
Citations - 10421
Hiroko Oshima is an academic researcher from Kanazawa University. The author has contributed to research in topics: Carcinogenesis & Wnt signaling pathway. The author has an hindex of 37, co-authored 83 publications receiving 9542 citations. Previous affiliations of Hiroko Oshima include Kyoto University & Merck & Co..
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Journal ArticleDOI
Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)
Masanobu Oshima,Joseph E. Dinchuk,Stacia Kargman,Hiroko Oshima,Bruno C. Hancock,Elizabeth Kwong,James M. Trzaskos,Jilly F. Evans,Makoto Mark Taketo,Makoto Mark Taketo +9 more
TL;DR: Results provide direct genetic evidence that COX-2 plays a key role in tumorigenesis and indicate that COx-2-selective inhibitors can be a novel class of therapeutic agents for colorectal polyposis and cancer.
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CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth
Takatsugu Ishimoto,Osamu Nagano,Toshifumi Yae,Mayumi Tamada,Takeshi Motohara,Hiroko Oshima,Masanobu Oshima,Tatsuya Ikeda,Rika Asaba,Hideki Yagi,Takashi Masuko,Takatsune Shimizu,Tomoki Ishikawa,Tomoki Ishikawa,Kazuharu Kai,Eri Takahashi,Yu Imamura,Yoshifumi Baba,Mitsuyo Ohmura,Makoto Suematsu,Hideo Baba,Hideyuki Saya +21 more
TL;DR: It is shown that a CD44 variant (CD44v) interacts with xCT, a glutamate-cystine transporter, and controls the intracellular level of reduced glutathione (GSH).
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TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis.
TL;DR: It is shown that chimeric mice showed several types of congenital anomalies, suggesting that TGF-beta II is important for normal development in a variety of organs.
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Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.
Masanobu Oshima,Hiroko Oshima,Kyoko Kitagawa,Masahiko Kobayashi,Chitoshi Itakura,Makoto Mark Taketo +5 more
TL;DR: Results indicate that loss of heterozygosity followed by formation of intravillous microadenomas is responsible for polyposis in Apc delta 716 intestinal mucosa, and it is therefore unlikely that the truncated product interacts directly with the wild-type protein and causes the microadenoma by a dominant negative mechanism.
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Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene
Minoru Matsui,Minoru Matsui,Masanobu Oshima,Hiroko Oshima,Kazuaki Takaku,Tetsuo Maruyama,Junji Yodoi,Makoto Mark Taketo +7 more
TL;DR: The phenotype of mice carrying a targeted disruption of the thioredoxin gene (Txn) is described and results indicate that Txn expression is essential for early differentiation and morphogenesis of the mouse embryo.