H
Hironori Waki
Researcher at University of Tokyo
Publications - 54
Citations - 18410
Hironori Waki is an academic researcher from University of Tokyo. The author has contributed to research in topics: Adipogenesis & Insulin resistance. The author has an hindex of 26, co-authored 47 publications receiving 17327 citations. Previous affiliations of Hironori Waki include Howard Hughes Medical Institute & University of California, Los Angeles.
Papers
More filters
Journal ArticleDOI
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Toshimasa Yamauchi,Junji Kamon,Hironori Waki,Yasuo Terauchi,Naoto Kubota,Kazuo Hara,Y. Mori,Tomohiro Ide,Kouji Murakami,Nobuyo Tsuboyama-Kasaoka,Osamu Ezaki,Y. Akanuma,Oksana Gavrilova,Charles Vinson,Marc L. Reitman,Hiroyuki Kagechika,Koichi Shudo,Madoka Yoda,Yasuko Nakano,Kazuyuki Tobe,R. Nagai,Shigeko Kimura,Motowo Tomita,Philippe Froguel,Takashi Kadowaki +24 more
TL;DR: It is concluded that decreased adiponectin is implicated in the development of insulin resistance in mouse models of both obesity and lipoatrophy and that the replenishment of adiponECTin might provide a novel treatment modality for insulin resistance and type 2 diabetes.
Journal ArticleDOI
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Toshimasa Yamauchi,Junji Kamon,Yasuhiko Minokoshi,Yoichi M. Ito,Hironori Waki,S. Uchida,Shigeo Yamashita,Mitsuhiko Noda,Shunbun Kita,K Ueki,Koji Eto,Y. Akanuma,Philippe Froguel,Fabienne Foufelle,Pascal Ferré,David Carling,Shigeko Kimura,Ryozo Nagai,Barbara B. Kahn,Takashi Kadowaki +19 more
TL;DR: It is shown that phosphorylation and activation of the 5′-AMP-activated protein kinase (AMPK) are stimulated with globular and full-length Ad in skeletal muscle and only with full- lengths Ad in the liver, indicating that stimulation of glucose utilization and fatty-acid oxidation by Ad occurs through activation of AMPK.
Journal ArticleDOI
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Toshimasa Yamauchi,Junji Kamon,Yusuke Ito,Atsushi Tsuchida,Takehiko Yokomizo,Takehiko Yokomizo,Shunbun Kita,Takuya Sugiyama,Makoto Miyagishi,Makoto Miyagishi,Kazuo Hara,Masaki Tsunoda,Koji Murakami,Toshiaki Ohteki,S. Uchida,Sato Takekawa,Hironori Waki,Nelson H. Tsuno,Yoichi Shibata,Yasuo Terauchi,Philippe Froguel,Kazuyuki Tobe,Shigeo Koyasu,Kazunari Taira,Kazunari Taira,Toshio Kitamura,Takao Shimizu,Takao Shimizu,Ryozo Nagai,Takashi Kadowaki +29 more
TL;DR: The cloning of complementary DNAs encoding adiponectin receptors 1 and 2 by expression cloning supports the conclusion that they serve as receptors for globular and full-length adiponECTin, and that they mediate increased AMP kinase and PPAR-α ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectionin.
Journal ArticleDOI
Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes MOLECULAR STRUCTURE AND MULTIMER FORMATION OF ADIPONECTIN
Hironori Waki,Toshimasa Yamauchi,Junji Kamon,Yusuke Ito,S. Uchida,Shunbun Kita,Kazuo Hara,Yusuke Hada,Francis Vasseur,Philippe Froguel,Satoshi Kimura,Ryozo Nagai,Takashi Kadowaki +12 more
TL;DR: It is demonstrated that simple SDS-PAGE under non-reducing and non-heat-denaturing conditions clearly separates multimer species of adiponectin.
Journal ArticleDOI
Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis
Toshimasa Yamauchi,Junji Kamon,Hironori Waki,Yasushi Imai,Nobuhiro Shimozawa,K. Hioki,S. Uchida,Yusuke Ito,Keisuke Takakuwa,Junji Matsui,Makoto Takata,Kazuhiro Eto,Yasuo Terauchi,Kajuro Komeda,Masaki Tsunoda,Koji Murakami,Yasuyuki Ohnishi,Takeshi Naitoh,Ken Ichi Yamamura,Yoshito Ueyama,Philippe Froguel,Satoshi Kimura,A. Ryozo Nagai,Takashi Kadowaki +23 more
TL;DR: It is shown that replenishment of globular adiponectin may provide a novel treatment modality for both type 2 diabetes and atherosclerosis, and this is the first demonstration that globular leptin can protect against Atherosclerosis in vivo.